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Anti-CD86 Antibody-APC (5D537)
还可以产品编号 TMAY-03702A
Anti-CD86 Antibody-APC (5D537) 是一种 APC-conjugated Mouse 抗体，靶向 CD86。Anti-CD86 Antibody-APC (5D537) 可用于 FCM。
Anti-CD86 Antibody-APC (5D537)
Anti-CD86 Antibody-APC (5D537)
还可以产品编号 TMAY-03702A
Anti-CD86 Antibody-APC (5D537) 是一种 APC-conjugated Mouse 抗体，靶向 CD86。Anti-CD86 Antibody-APC (5D537) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-CD86 Antibody-APC (5D537) is a APC-conjugated Mouse antibody targeting CD86. Anti-CD86 Antibody-APC (5D537) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 5D537 |
| 交叉反应 | Rat |
| 验证活性 | Flow cytometric analysis of rat CD86 expression on LPS-stimulated SD rat splenocytes. Cells were stained with APC-conjugated anti-rat CD86. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD86 (rR CD86; TMPY-02016; NP_064466.1; Met1-Ile250) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/HRP/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Rat CD86 Protein (TMPY-02016) |
| 抗原种属 | Rat |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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