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Anti-Phospho-NBN (Ser343) Antibody (4A426)
还可以产品编号 TMAH-00934
别名 Phospho-NBN (S343), p95 protein of the MRE11/RAD50 complex, p95, Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome 1, Nijmegen breakage syndrome, Nibrin, nibrin, NBS1, NBS 1, NBS, MGC87362, FLJ10155, Cell cycle regulatory protein p95, ATV, AT V2, AT V1
Anti-Phospho-NBN (Ser343) Antibody (4A426) 是一种抗体，靶向 Phospho-NBN (Ser343)。Anti-Phospho-NBN (Ser343) Antibody (4A426) 可用于 ELISA, WB。
Anti-Phospho-NBN (Ser343) Antibody (4A426)
Anti-Phospho-NBN (Ser343) Antibody (4A426)
还可以产品编号 TMAH-00934 别名 Phospho-NBN (S343), p95 protein of the MRE11/RAD50 complex, p95, Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome 1, Nijmegen breakage syndrome, Nibrin, nibrin, NBS1, NBS 1, NBS, MGC87362, FLJ10155, Cell cycle regulatory protein p95, ATV, AT V2, AT V1
Anti-Phospho-NBN (Ser343) Antibody (4A426) 是一种抗体，靶向 Phospho-NBN (Ser343)。Anti-Phospho-NBN (Ser343) Antibody (4A426) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Phospho-NBN (Ser343) Antibody (4A426) is an antibody targeting Phospho-NBN (Ser343). Anti-Phospho-NBN (Ser343) Antibody (4A426) can be used in ELISA, WB. |
| 别名 | Phospho-NBN (S343), p95 protein of the MRE11/RAD50 complex, p95, Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome 1, Nijmegen breakage syndrome, Nibrin, nibrin, NBS1, NBS 1, NBS, MGC87362, FLJ10155, Cell cycle regulatory protein p95, ATV, AT V2, AT V1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 4A426 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in Hela whole cell lysate,HepG2 whole cell lysate -All lanes Phospho-NBN antibody at 1.98μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 95 KDa -Observed band size: 95 KDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Nucleus, PML body. Chromosome, telomere. Chromosome. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-NBN (S343) |
| 抗原种属 | Human |
| 基因ID | 4683 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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