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Anti-CD86 Antibody-PE (5D537)
还可以产品编号 TMAY-03702P
Anti-CD86 Antibody-PE (5D537) 是一种 PE-conjugated Mouse 抗体，靶向 CD86。Anti-CD86 Antibody-PE (5D537) 可用于 FCM。
Anti-CD86 Antibody-PE (5D537)
Anti-CD86 Antibody-PE (5D537)
还可以产品编号 TMAY-03702P
Anti-CD86 Antibody-PE (5D537) 是一种 PE-conjugated Mouse 抗体，靶向 CD86。Anti-CD86 Antibody-PE (5D537) 可用于 FCM。
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| 产品描述 | Anti-CD86 Antibody-PE (5D537) is a PE-conjugated Mouse antibody targeting CD86. Anti-CD86 Antibody-PE (5D537) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 5D537 |
| 交叉反应 | Rat |
| 验证活性 | Flow cytometric analysis of rat CD86 expression on LPS-stimulated SD rat splenocytes. Cells were stained with PE-conjugated anti-rat CD86. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD86 / B7-2 (rR CD86 / B7-2; TMPY-02016; NP_064466.1; Met1-Ile250) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/FITC/HRP |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Rat CD86 / B7-2 Protein (TMPY-02016) |
| 抗原种属 | Rat |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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