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Anti-Alpha-2-macroglobulin Antibody (9L785)
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产品编号 TMAC-00039
别名 α-2-macroglobulin, S863-7, FWP007, CPAMD5, alpha-2-macroglobulin, A2MD
Anti-Alpha-2-macroglobulin Antibody (9L785) 是一种 Rabbit 抗体，靶向 Alpha-2-macroglobulin。Anti-Alpha-2-macroglobulin Antibody (9L785) 可用于 WB,IHC。
Anti-Alpha-2-macroglobulin Antibody (9L785)
Anti-Alpha-2-macroglobulin Antibody (9L785)
还可以产品编号 TMAC-00039 别名 α-2-macroglobulin, S863-7, FWP007, CPAMD5, alpha-2-macroglobulin, A2MD
Anti-Alpha-2-macroglobulin Antibody (9L785) 是一种 Rabbit 抗体，靶向 Alpha-2-macroglobulin。Anti-Alpha-2-macroglobulin Antibody (9L785) 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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| 产品描述 | Anti-Alpha-2-macroglobulin Antibody (9L785) is a Rabbit antibody targeting Alpha-2-macroglobulin. Anti-Alpha-2-macroglobulin Antibody (9L785) can be used in WB,IHC. |
| 别名 | α-2-macroglobulin, S863-7, FWP007, CPAMD5, alpha-2-macroglobulin, A2MD |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of A2M on human placenta cells lysates using anti-A2M antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-A2M antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-A2M antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-A2M antibody. Counter stained with hematoxylin. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | α-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor that was able to "bait" proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to "trap" the proteinase and further inhibit its activity. Subsequently, α-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serum is primarily bound to α-2M, which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer's Disease (AD), which is consistent with the role of α-2M in mediating the clearance and degradation of A β, the major component of β-Amyloid deposits accumulated during AD. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 163 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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