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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RAD50 Polyclonal Antibody

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货号 TMAB-12039

Anti-RAD50 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RAD50。Anti-RAD50 Polyclonal Antibody 可用于 WB,FCM。

Anti-RAD50 Polyclonal Antibody

Anti-RAD50 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12039

Anti-RAD50 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RAD50。Anti-RAD50 Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-RAD50 Polyclonal Antibody is a Rabbit antibody targeting RAD50. Anti-RAD50 Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Cow,Horse,Rabbit,Sheep)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 0.2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents.
组织特异性Expressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
抗原信息
免疫原
KLH conjugated synthetic peptide: human RAD50
抗原种属
Human
基因名称
RAD50
基因ID
10111
蛋白名称
DNA repair protein RAD50
Uniprot ID
Q92878
功能
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
化学信息
分子量Theoretical: 154 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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