169
64
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316
Cat. No. | Product Name | ||
---|---|---|---|
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38622 |
Bcl-xL antagonist 2
|
BCL | Apoptosis |
Bcl-xL antagonist 2 是一种有效的选择性 Bcl-xL 拮抗剂,IC50 为 91 nM,Ki 为 65 nM。 Bcl-xL antagonist 2 可诱导癌细胞凋亡,可用于慢性淋巴细胞白血病和非霍奇金淋巴瘤的研究。 | |||
T10483 |
Lisaftoclax
Bcl-2/Bcl-xl inhibitor 1,APG-2575 |
BCL | Apoptosis |
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50:2 nM 和 5.9 nM),具有抗肿瘤活性。 | |||
T33467 |
MOMIPP
|
PI3K | PI3K/Akt/mTOR signaling |
MOMIPP 是一种 PIKfyve 抑制剂,是一种巨胞饮作用的诱导剂,可穿过血脑屏障 (BBB)。 | |||
T39961 |
Bcl-2-IN-2
|
||
Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL. It displays an IC50 value of 0.034 nM, suggesting its strong inhibitory activity specifically against Bcl-2. Additionally, Bcl-2-IN-2 exhibits an IC50 value of 43 nM against Bcl-xL, demonstrating over 1000-fold selectivity for Bcl-2 compared to Bcl-xL. | |||
T17018 |
TCPOBOP
|
BCL | Apoptosis |
TCPOBOP 是一种组成型雄烷受体激动剂,可诱导强大的肝细胞增殖和肝肿大。它通过改变 Bcl-2 蛋白来减少 Fas 诱导的小鼠肝损伤。 | |||
T11969 |
MCL-1/BCL-2-IN-2
|
Others | Others |
MCL-1/BCL-2-IN-2 is a potent and selective Bcl-2 and Mcl-1 dual inhibitor. | |||
T12824L |
S55746
BLC201 |
BCL | Apoptosis |
S55746 (BLC201) 是一种有效、可口服、选择性的BCL-2抑制剂,其Ki 值和Kd 值分别为 1.3 nM 和 3.9 nM。它具有抗肿瘤活性且毒性低。 | |||
T11971 |
MCL-1/BCL-2-IN-4
|
Others | Others |
MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor. | |||
T11970 |
MCL-1/BCL-2-IN-3
|
Others | Others |
MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely. | |||
T11968 | MCL-1/BCL-2-IN-1 | BCL | Apoptosis |
MCL-1/BCL-2-IN-2 (Compound Nap-1) 是一种有效的选择性 Mcl-1和 Bcl-2双重抑制剂,IC50分别为 4.45 和 3.18 μM。 | |||
T2099 |
ABT-737
|
Mitophagy; BCL; Autophagy | Apoptosis; Autophagy |
ABT737 是 BH3 模拟物,是Bcl-2、Bcl-xL 和Bcl-w 抑制剂,EC50分别为 30.3 nM、78.7 nM 和 197.8 nM。它诱导自噬,有研究急性髓系白血病的潜力。它还诱导 BCL-2/BAX 复合物的破坏和 BAK 依赖性。 | |||
T11944 |
Maritoclax
Marinopyrrole A |
BCL | Apoptosis |
Maritoclax (Marinopyrrole A) 是一种新型特异性 Mcl-1 抑制剂,IC50值为 10.1 μM,对 BCL-xl 的 IC50值 > 80 μM。 | |||
T1980 |
HA14-1
|
BCL | Apoptosis |
HA14-1 是一种 Bcl-2/Bcl-xL 拮抗剂,与 Bcl-2 上的特定口袋结合,IC50约为 9 μM。 | |||
T6650 |
Sabutoclax
BI-97C1 |
BCL | Apoptosis |
Sabutoclax (BI-97C1) 是一种泛 Bcl-2 抑制剂,包括 Bcl-xL、Bcl-2、Mcl-1 和 Bfl-1,IC50 分别为 0.31 μM、0.32 μM、0.20 μM 和 0.62 μM。 | |||
T14071 |
A-385358
|
BCL | Apoptosis |
A-385358 是一种特异性 Bcl-xL 抑制剂,对 Bcl-xL 和 Bcl-2 的 Ki 分别为 0.80 nM 和 67 nM。 | |||
T5108 |
ML311
|
BCL | Apoptosis |
ML311 是 Mcl-1/Bim 相互作用的一种选择性抑制剂。 | |||
T5408 |
BI-3802
|
BCL | Apoptosis |
BI-3802 能够抑制 BCL6 的Bric-à-brac (BTB) 结构域,IC50 ≤3 nM。它可诱导 BCL6 蛋白聚集,并促进 E3 连接酶SIAH1介导的蛋白降解。BI-3802显示出抗肿瘤活性。 | |||
T2632 |
A-1210477
|
Apoptosis; BCL | Apoptosis |
A-1210477 是一种选择性的MCL-1有效抑制剂,Ki 值为 0.45 nM。它特异性结合 MCL-1,并以 MCL-1 依赖性方式促进癌细胞凋亡。 | |||
T14834 |
BT2
3,6-二氯-2-苯并噻吩羧酸 |
BCL | Apoptosis |
BT2 是 BCKDC 激酶(BDK)抑制剂,IC50值为 3.19 μM。它也是一种选择性的Mcl-1抑制剂,Ki 值为 59 μM。BT2 与 BDK 结合触发 N 端结构域的螺旋运动,导致 BDK 从支链 α-酮酸脱氢酶复合物 (BCKDC) 中解离。 | |||
T5346 |
S63845
|
BCL | Apoptosis |
S63845 是一种选择性骨髓细胞白血病 1 抑制剂,结合人 MCL1的 Kd 值为 0.19 nM。 | |||
T6281 |
TW-37
TW 37 |
BCL | Apoptosis |
TW-37 是重组 Bcl-2、Bcl-xL 和 Mcl-1 的非肽抑制剂,Ki 值分别为 0.26、0.29和1.11μM | |||
T14376 |
AZD4320
|
BCL | Apoptosis |
AZD4320 是一种BCL2/BCLxL 双重抑制剂,是 BH-3 类似物,对 KPUM-MS3、KPUM-UH1 和 STR-428 细胞,IC50 值分别为 26 nM、17 nM 和 170 nM。 | |||
T2453 |
BAM7
|
BCL | Apoptosis |
BAM7 是一种促凋亡 Bax 的直接和特异性激活剂,IC50为 3.3 μM。 | |||
T14561 |
BI-3812
|
BCL | Apoptosis |
BI-3812 是一种高效的BCL6抑制剂,具有抗肿瘤活性,能够抑制 BCL6 的 BTB 结构域,IC50值 ≤3 nM。 | |||
T6749 |
A-1331852
|
BCL | Apoptosis |
A1331852是一种具有口服活性的BCL-XL 选择性抑制剂,Ki 值小于10 pM。它可用于治疗癌症、免疫和自身免疫疾病。 | |||
T4089 |
FX1
|
Apoptosis; BCL | Apoptosis |
FX1 是一种强效特异性BCL6抑制剂,IC50大约为 35 μM。 | |||
T6034 |
UMI-77
UMI77,UMI 77 |
BCL | Apoptosis |
UMI-77是一种选择性的Mcl-1抑制剂,结合到Mcl-1的 BH3 结合沟,Ki 值为 490 nM,对 Bcl-2 家族的其他成员具有选择性。 | |||
T2101 |
Navitoclax
ABT-263 |
BCL | Apoptosis |
Navitoclax (ABT-263) 是一种 Bcl-2 抑制剂,可与 Bcl-xL、Bcl-2、Bcl-w 等蛋白结合 (Ki<1 nM),具有有效性和口服活性。Navitoclax 具有抗肿瘤活性,可以诱导细胞凋亡。 | |||
T7538 |
Tetraethylammonium chloride
|
Potassium Channel | Membrane transporter/Ion channel |
Tetraethylammonium chloride 是非选择性钾通道阻滞剂。它是有机阳离子转运蛋白的良好底物,并具有抗肿瘤特性。 | |||
T3940 |
CID5721353
BCL6 inhibitor |
Apoptosis; BCL | Apoptosis |
CID5721353 (BCL6 inhibitor) 是一种 B 细胞淋巴瘤 6 抑制剂,IC50为 212 μM,Ki 值为 147 μM。它可在体内外破坏 BCL6/辅助阻遏物复合物,并显示与 BTB 沟内的关键位点结合。 | |||
T6748 |
A-1155463
A 1155463,A1155463,醋酸艾塞那肽 |
BCL | Apoptosis |
A-1155463是一种高效选择性的BCL-XL 抑制剂,对 BCL-XL 具有皮摩尔的结合亲和力,在Molt-4细胞中的EC50值为70 nM。 | |||
T6778 |
BDA-366
|
BCL | Apoptosis |
BDA-366 是一种有效的 Bcl2 拮抗剂,以高亲和力和选择性 (Ki = 3.3 nM) 结合 Bcl2-BH4 结构域。 BDA-366 诱导 Bcl2 的构象变化,从而消除其抗凋亡功能,将其从存活分子转变为细胞死亡诱导剂。 BDA-366 抑制肺癌细胞的生长。 | |||
T5210 |
BAI1
|
Apoptosis; BCL | Apoptosis |
BAI1 是一种选择性凋亡因子BAX 变构抑制剂。它结合 BAX 并变构抑制其激活,具有潜力研究 BAX 依赖性细胞死亡介导的疾病。 | |||
T6258 |
Zibotentan
ZD4054 |
Apoptosis; Endothelin Receptor | Apoptosis; GPCR/G Protein |
Zibotentan (ZD4054) 是一种选择性的,具有口服活性的内皮素 A (ETA) 受体拮抗剂,Ki 为 13 nM。它具有抗癌作用,可研究去势抵抗性前列腺癌。 | |||
T5104 |
BTSA1
|
Apoptosis; BCL | Apoptosis |
BTSA1 是一种有口服活性的 BAX 激活剂,IC50为 250 nM,EC50为 144 nM。它以高亲和力和特异性与 N 末端激活位点结合,并诱导 BAX 发生构象变化,从而导致BAX 介导的细胞凋亡。 | |||
T8656 |
CAY10404
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis; Akt; COX | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSC-LC 细胞凋亡,具有镇痛、抗炎和抗癌活性。 | |||
T16028 |
IMB-XH1
Mcl1-IN-2,7-[(2-吡啶基氨基)-2-噻吩基甲基]-8-喹啉醇 |
BCL; Antibacterial | Apoptosis; Microbiology/Virology |
IMB-XH1 (Mcl1-IN-2) 是一种骨髓细胞因子 1 抑制剂。它也是非竞争性的 Delhi metallo-β-lactamase(NDM-1) 抑制剂。它对金属 β-内酰胺酶 NDM-1,IMP-4,ImiS 和 L1 的 IC50值分别为 0.4637 μM,3.980 μM,0.2287 μM 和 1.158 μM。 | |||
T15771 |
Lobaplatin
D-19466,络铂 |
DNA Alkylation | DNA Damage/DNA Repair |
Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物,是一种有前途的抗肿瘤化疗药物,在多种肿瘤类型的患者中具有活性。 | |||
T5827 |
BI-6C9
|
Apoptosis; Others; Mitochondrial Metabolism | Apoptosis; Metabolism; Others |
BI-6C9 是一种高特异性的 BH3 相互作用结构域抑制剂,可阻止线粒体外膜电位和线粒体分裂,并保护细胞免受线粒体凋亡诱导因子释放和不依赖 caspase 的细胞死亡。 | |||
T12041 |
MIM1
Inhibitor of Mcl-1 |
BCL | Apoptosis |
MIM1 (Inhibitor of Mcl-1) 是一种骨髓细胞因子 1 抑制剂。 | |||
T6275 |
Obatoclax Mesylate
Obatoclax,GX15-070,奥巴克拉甲磺酸盐 |
BCL; Parasite; Autophagy | Apoptosis; Autophagy; Microbiology/Virology |
Obatoclax Mesylate (GX15-070) 是泛 BCL-2家族蛋白抑制剂,对 BCL-2 的 Ki 值为 220 nM。它是 BH3 模拟物,具有抗癌和广谱抗寄生虫活性。它诱导自噬依赖性细胞死亡,并靶向细胞周期蛋白 D1 进行蛋白酶体降解。 | |||
T12186 |
Navitoclax-piperazine
ABT-263-piperazine |
BCL; Ligands for Target Protein for PROTAC | Apoptosis; PROTAC |
Navitoclax-piperazine (ABT-263-piperazine) 是一种特大型 B 细胞淋巴瘤(BCL-XL)抑制剂。它和 E3 泛素连接酶的 VHL 配体可用来合成 PROTAC DT2216。 | |||
T2119 |
Venetoclax
GDC-0199,ABT 199,维奈妥拉,ABT-199,ABT199 |
BCL; Autophagy | Apoptosis; Autophagy |
Venetoclax (ABT-199) 是一种 Bcl-2 抑制剂 (Ki<0.01 nM),具有高效性、选择性和口服活性。Venetoclax 与 Bcl-xL 和 Bcl-W 的亲和力降低了 3 个数量级(Kis=48/245 nM)。Venetoclax 可以诱导自噬和凋亡。 | |||
T9083 |
TC11
CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 |
BCL; Caspase; CDK | Apoptosis; Cell Cycle/Checkpoint; Proteases/Proteasome |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂,并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间,它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。 | |||
T1493 |
BH3I-1
BHI1 |
BCL; E1/E2/E3 Enzyme | Apoptosis; Ubiquitination |
BH3I-1 (BHI1) 是一种Bcl-2家族拮抗剂,作用于p53/mDM2,Kd 为 5.3 μM。它抑制BakBH3 肽与Bcl-xL 结合,Ki 为 2.6 μM。 | |||
T13416 |
ZX-29
|
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
ZX-29 是一种选择性ALK 抑制剂,对ALK、ALK L1196M 和ALK G1202R 的IC50分别为 2.1 nM、1.3 nM 和 3.9 nM。它还可诱导保护性自噬并具有抗肿瘤作用。它通过诱导内质网应激来诱导细胞凋亡,并克服了由ALK 突变引起的细胞抗性。 | |||
T6941 |
PI-1840
PI 1840 |
PARP; Proteasome | Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination |
PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂,IC50=27nM。 | |||
T39910 |
Desmorpholinyl Navitoclax-NH-Me
Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me |
BCL | Apoptosis |
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2]. | |||
T62443 |
Bcl-2/Mcl-1-IN-2
|
||
Bcl-2/Mcl-1-IN-2 是一种 Bcl-2 (Ki: 4.70 μM) 和 Mcl-1 (Ki: 0.88 μM) 抑制剂。Bcl-2/Mcl-1-IN-2 能够用于研究癌症。 | |||
T6396 |
(R)-(-)-Gossypol acetic acid
(-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101醋酸,AT101,AT101 acetate |
BCL; Autophagy | Apoptosis; Autophagy |
(R)-(-)-Gossypol acetic acid (AT101 acetate) 是天然产物 Gossypol 的左旋异构体,与 Bcl-2、Bcl-xL 和 Mcl-1 结合,Ki 为 0.32 μM、0.48 μM 和 0.18 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
TN1406 |
Dihydrokaempferol
香橙素,Aromadendrin |
Apoptosis; BCL | Apoptosis |
Dihydrokaempferol (Aromadendrin) 是从紫荆花中分离得到的一种天然产物,诱导凋亡并抑制 Bcl-2 和 Bcl-xL 的表达,可以作为抗关节炎的良好新药候选。 | |||
T8213 |
Isolinderalactone
|
NOS; STAT | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Isolinderalactone 具有抗炎和抗癌能力,具有中等的 iNOS 抑制活性,IC50 值为 0.30 uM。 | |||
TN3967 |
Epieriocalyxin A
|
ERK; BCL; ROS; Caspase; DNA/RNA Synthesis; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Proteases/Proteasome |
Epieriocalyxin A 可以抑制 Caco-2 结肠癌细胞的生长。它可能是未来结肠癌治疗的潜在药物。 | |||
T7979 |
2-Hydroxychalcone
2-(2-Hydroxybenzal)Acetophenone,2-羟基查酮 |
Apoptosis; BCL; Others; NF-κB | Apoptosis; NF-κB; Others |
2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) 是一种天然黄酮,可通过下调 Bcl-2 诱导凋亡,也可抑制NF-kB 的激活。它是抗氧化剂,抑制脂质过氧化,还可抑制三阴性乳腺癌细胞的侵袭。 | |||
T6518 |
Gossypol
Pogosin,BL 193,棉酚,NSC 56817 |
BCL; Dehydrogenase | Apoptosis; Metabolism |
Gossypol (BL 193) 是一种多酚醛,可渗透细胞并作为几种脱氢酶的抑制剂。它分别与 Bcl-xL 蛋白和Bcl-2蛋白结合,Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。 | |||
T6S0052 |
Chelerythrine
Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine |
Apoptosis; BCL; PKC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling |
Chelerythrine (Broussonpapyrine) 是一种天然生物碱,为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂,IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合,IC50为 1.5 μM,并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。 | |||
T6S1653 |
Albiflorin
Alibiflorin,芍药内酯苷 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分,是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。 | |||
T3419 |
Chelerythrine chloride
白屈菜红碱,盐酸白屈菜红碱 |
Apoptosis; BCL; PKC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling |
Chelerythrine chloride 是一种可渗透细胞的蛋白激酶 C 抑制剂,对磷酸盐受体具有竞争性,而对 ATP 是非竞争性的。它诱导细胞凋亡和自噬。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T2S0500 |
Ilexsaponin A
毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1 |
Others | Others |
Ilexsaponin A (Ilexsaponin A1)1 是分离自冬凌草的根中,利用抗凋亡途径减轻缺血再灌注引起的心肌损伤。它能够减少心肌梗塞的大小,减少 LDH,AST 和 CK-MB 的血清水平,促进细胞活力并抑制缺氧/复氧心肌细胞的凋亡。 | |||
T10990 |
Dehydrocorydaline chloride
盐酸脱氢紫堇碱,13-Methylpalmatine chloride |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达;激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T6185 |
Gambogic Acid
藤黄酸,Beta-Guttiferrin,藤黄酸 A,Guttatic Acid,Guttic Acid |
BCL; Autophagy | Apoptosis; Autophagy |
Gambogic Acid (Guttic Acid) 是来自藤黄树的一种藤黄树脂,抑制 Bcl-XL、Bcl-2、Bcl-W、Bcl-B、Bfl-1和 Mcl-1,IC50分别为 1.47 μM、1.21 μM、2.02 μM、0.66 μM、1.06 μM 和 0.79 μM。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
T5679 |
(E)-Ferulic acid
trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid |
BCL; Ferroptosis; Wnt/beta-catenin; Endogenous Metabolite | Apoptosis; Cytoskeletal Signaling; Metabolism; Stem Cells |
(E)-Ferulic acid ((E)-Coniferic acid) 是阿魏酸的异构体,阿魏酸是在植物细胞壁中丰富存在的芳香族天然产物。 它引起 β-catenin 的磷酸化,导致其蛋白酶体降解,增加促凋亡因子 Bax 的表达,降低促生存因子的表达。它在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。 | |||
T2764 |
(S)-10-Hydroxycamptothecin
10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡,可研究肝癌、胃癌、结肠癌和白血病。 | |||
T3322 |
trans-Chalcone
Chalcone,反-查耳酮,查尔酮,Cinnamophenone,Chalkone |
Apoptosis; Others; Antifungal; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Others |
trans-Chalcone (Chalkone) 是从 Aronia melanocarpa 果皮中分离出来的一种天然产物,是类黄酮前体的双酚核心结构。它是脂肪酸合酶和 α-淀粉酶的抑制剂,具有抗真菌和抗癌活性。 | |||
T3344 |
Ciwujianoside B
yemuoside YM,刺五加皂苷 B,acanthopanax senticosides B,刺五加皂甙 B,Ciwujianoside-B |
BCL; Others | Apoptosis; Others |
Ciwujianoside B (acanthopanax senticosides B) 是刺五加的主要成分,能缓解疲劳,增强记忆力,提高人的认知能力。 | |||
T2730 |
Gossypol (acetic acid)
(±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid |
BCL | Apoptosis |
Gossypol acetic acid (AT101) 是一种从棉籽中分离出来的多酚天然产物,分别与 Bcl-xL 蛋白和 Bcl-2蛋白结合,Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。 | |||
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 | |||
T2851 |
Daphnetin
7,8-Dihydroxycoumarin,Daphnetol,瑞香素 |
EGFR; PKA; PKC; Parasite; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Daphnetin (7,8-Dihydroxycoumarin) 是从 Genus Daphne 中分离得到的香豆素衍生物,有抗氧化、抗炎、抗疟疾和解热作用,可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究。 | |||
T4085 |
Paris saponin VII
重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII |
Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位,增加凋亡相关蛋白的表达,并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬,可研究白血病。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
T6S1917 |
Schisandrol B
Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B |
P450; Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Schisandrol B (Besigomsin) 是华中五味子的主要活性成分,具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生,也抑制 P-糖蛋白和CYP3A 的活性。 | |||
T1034 |
Docetaxel
多西他赛,NSC 628503,RP-56976,多烯紫杉醇 |
Apoptosis; Microtubule Associated; Endogenous Metabolite | Apoptosis; Cytoskeletal Signaling; Metabolism |
Docetaxel (RP-56976) 是紫杉醇的半合成类似物,是一种微管解聚抑制剂 (IC50=0.2 μM)。Docetaxel 可以减弱 bcl-2 和 bcl-xL 基因表达的影响,具有诱导凋亡、抗肿瘤活性。 | |||
T3857 |
magnolin
木兰脂素,(+)-Magnolin,木兰苷 |
ERK | MAPK |
Magnolin 是辛夷的一种主要成分,靶向作用于ERK1和ERK2,IC50值分别为 87 和 16.5 nM,可抑制Ras/ERKs/RSK2信号通路。它在体内外降低肾脏氧化应激,抑制 caspase-3 活性,并增加 Bcl-2 表达,具有抗炎和抗氧化作用。 | |||
T6S1529 |
Cynarin
Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-,Cynarine,1,5-Dicaffeoylquinic acid,洋蓟素,金银花 |
Antioxidant; Antiviral; Influenza Virus; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction |
Cynarin (1,5-Dicaffeoylquinic acid) 是一种抗窒息剂,具有抗氧化、抗组胺和抗病毒等多种生物活性。 | |||
T2S0410 |
Euphorbia factor L1
Euphorbiasteroid,大戟因子L1,大戟因子 L1 |
Apoptosis; P-gp | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬,具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。 | |||
T5S2083 |
Puerarin 6''-O-Xyloside
|
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Puerarin 6''-O-Xyloside 是从葛根中分离得到的一种天然产物,可诱导线粒体介导的细胞凋亡通路,有抗炎和抗癌活性。 | |||
T3867 |
Alpinetin
山姜素,(-)-alpinetin |
BCL; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Alpinetin ((-)-alpinetin) 是从草豆蔻中分离得到的一种黄酮类天然产物,能够活化PPAR-γ,具有抗炎、抗菌活性。它通过抑制增殖、调节 Bcl-2 家族和 XIAP 表达、释放细胞色素 c 和激活 caspase 具有很强的抗肝癌和胰腺癌细胞作用。 | |||
T7027 |
EURYCOMANONE
东革阿里提取物,Pasakbumin A |
Others | Others |
Eurycomanone (Pasakbumin A) 能够抑制雌激素生成过程中磷酸二酯酶和芳香酶的活性,促进精子生成。它对 HepG2 细胞具有细胞毒性,能够上调 p53 和 Bax 以及下调 Bcl-2 ,诱导细胞凋亡。它具有抗癌活性,在浓度范围内以剂量依赖性方式抑制 A549 肺癌细胞增殖 从 5 到 20 微克/毫升。 | |||
T2795 |
Amygdalin
苦杏仁苷,Laetrile |
Others | Others |
Amygdalin (Laetrile) 是一种植物葡萄糖苷,分离自蔷薇果实的果核中,如杏,桃,杏仁,樱桃和李子。 | |||
T6S1418 |
Praeruptorin C
|
Antioxidant; Calcium Channel | Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Praeruptorin C 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.7。 | |||
TN2254 |
Taccalonolide A
根薯酮内酯A,根薯酮内酯 A |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Taccalonolide A 是从水田七根茎中分离得到的一种类固醇,具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用,抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂,能引起 G2-M 期滞留、Bcl-2 磷酸化,并引发细胞凋亡。 | |||
T3S2344 |
β,β-Dimethylacrylshikonin
β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin |
ERK; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; MAPK; Metabolism |
β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物,从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达,促进血管生成,具有抗肿瘤活性。 | |||
T2860 |
Vanillyl Alcohol
4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol |
Apoptosis; Others | Apoptosis; Others |
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇,具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来,在食品和饮料中用作调味剂。 | |||
TN2103 |
PROCYANIDIN C1
原花青素 C1,原花青素C1 |
Apoptosis | Apoptosis |
Procyanidin C1 是一种天然多酚,可造成 DNA 损伤,细胞周期停滞,诱导凋亡。它降低癌细胞中 Bcl-2 的蛋白水平,增强 BAX,caspase 3 和 9 的表达。 | |||
T2823 |
Crocin
西红花苷,藏红花,Gardenia Yellow,Alpha-Crocin,藏红花素 |
Others | Others |
Crocin (Gardenia Yellow) 是从Crocus sativus 柱头中分离出的主要成分,是一种营养保健品,具有抗炎,抗癌,抗抑郁和抗惊厥等强大的药理作用。 | |||
T6S0653 |
Linarin
Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷 |
TNF; AChE | Apoptosis; Neuroscience |
Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂,从薄荷花提取物中分离得到。 | |||
T6S0735 |
Flavokawain B
黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone |
Apoptosis; Others | Apoptosis; Others |
Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中,分离出的查尔酮。它是一种凋亡诱导剂,可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成,具有抗血管生成活性。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T3895 |
Polyphyllin I
重楼皂苷I,重楼皂甙 |
Apoptosis; Akt; JNK; PDK; mTOR; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T3923 |
Calycosin
Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮 |
Apoptosis; Tyrosinase | Apoptosis; Proteases/Proteasome |
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。 | |||
T2966 |
Beta-Sitosterol
Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost |
Apoptosis; Lipase; Endogenous Metabolite | Apoptosis; Metabolism |
Beta-Sitosterol (SKF 14463) 是一种植物甾醇,干扰细胞周期、细胞凋亡、增殖、存活、侵袭、血管生成和炎症等多种细胞信号通路。 | |||
T3864 |
Erianin
|
BCL; Antibacterial | Apoptosis; Microbiology/Virology |
Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成,可用作退烧药和止疼剂。 | |||
T2698 |
Asperosaponin VI
Akebia saponin D,Asperosaponin Ⅵ,川续断皂苷 VI |
Apoptosis; Others; Caspase | Apoptosis; Others; Proteases/Proteasome |
Asperosaponin VI (Akebia saponin D) 是一种来自续断壁的皂苷组分。它通过增加 Bcl-2/Bax 比值,降低活性 caspase-3 表达,以及增强 p-Akt 和 p-CREB,从而抑制缺氧诱导的心肌细胞凋亡。它通过 BMP-2/p38 和 ERK1/2 信号途径诱导成骨细胞分化。 | |||
T0186 |
Docetaxel trihydrate
RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物 |
Apoptosis; BCL; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂,抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物,能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期,导致细胞凋亡。 | |||
T5S0661 |
Koumine
|
Others | Others |
Koumine 是一种从钩吻中得到的生物碱,具有高效抗肿瘤活性,在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中,它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用,也可用于缓解疼痛的研究。 | |||
TN3653 | Cimidahurinine | BCL; ROS | Apoptosis; Immunology/Inflammation |
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins. | |||
T81229 | Safflor yellow B | ||
Safflor yellow B 通过抑制血管紧张素 II 介导的人脐静脉细胞损伤,调节 Bcl-2/p22 (phox) 表达,展现出神经保护作用。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02700 |
BCL2 Protein, Human, Recombinant (His)
Bcl-2,PPP1R50,B-cell CLL/lymphoma 2 |
Human | E. coli |
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins... | |||
TMPJ-00717 |
BAG2 Protein, Human, Recombinant (His)
BAG-2,BAG Family Molecular Chaperone Regulator ... |
Human | E. coli |
BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. | |||
TMPH-02520 |
BCL2 Protein, Mouse, Recombinant (His)
Bcl2,Apoptosis regulator Bcl-... |
Mouse | E. coli |
BCL2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.7 kDa and the accession number is P10417. | |||
TMPH-03245 |
BCL2 Protein, Rat, Recombinant (His)
Bcl2,Apoptosis regulator Bcl-... |
Rat | E. coli |
BCL2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 28.1 kDa and the accession number is P49950. | |||
TMPJ-00584 |
Bc1-w Protein, Human, Recombinant (His)
Apoptosis Regulator Bcl-W,KIAA0271,Bcl... |
Human | E. coli |
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone... | |||
TMPY-02004 |
BCL-W Protein, Human, Recombinant (His)
BCL2-L-2,BCL-W,BCL |
Human | E. coli |
BCL-W Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20 kDa and the accession number is Q92843-1. | |||
TMPH-02534 |
BAG3 Protein, Mouse, Recombinant (His)
Bcl-2-associated athanogene 3,Bag3,Bcl... |
Mouse | P. pastoris (Yeast) |
BAG3 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63.7 kDa and the accession number is Q9JLV1. | |||
TMPH-02535 |
BAG3 Protein, Mouse, Recombinant (His & SUMO)
Bcl-2-associated athanogene 3,Bis,BAG-3,BA... |
Mouse | E. coli |
BAG3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 77.7 kDa and the accession number is Q9JLV1. | |||
TMPJ-00038 |
IL-7 Protein, Mouse, Recombinant (His)
interleukin-7,白介素,IL-7,IL-7 interleukin-7,PBGF,Lymphopoietin... |
Mouse | HEK293 Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell... | |||
TMPY-03974 |
Bim Protein, Human, Recombinant (His)
BAM,BCL2-like 11 (apoptosis facilitator),B... |
Human | E. coli |
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymoc... | |||
TMPK-00636 |
BID Protein, Mouse, Recombinant (His)
BID,p22 BID |
Mouse | E. coli |
Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. Bid is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. Bid is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. | |||
TMPH-00535 |
Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)
|
EBV | E. coli |
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell. | |||
TMPY-02001 |
RTN4 Protein, Human, Recombinant (GST)
UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOGO-A,RTN-X... |
Human | E. coli |
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ... | |||
TMPY-04768 |
PRPS2 Protein, Human, Recombinant (His)
PRPS2,PRSII,phosphoribosyl pyrophosphate synthetase... |
Human | E. coli |
PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway. The gene for PRS II (PRPS2) is located at a different region of the X chromosome, namely Xpter-a21. The promoter region of the human PRPS2 gene was also GC-rich and contained a TATA-like sequence, four Sp1 binding sites and a homopyrimidine... | |||
TMPJ-00455 |
SLAMF5 Protein, Mouse, Recombinant (His)
CD84 molecule,SLAM family member 5,Leukocyte differentiation... |
Mouse | HEK293 Cells |
CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hemato... | |||
TMPJ-01066 |
CYCS Protein, Human, Recombinant (His)
CYC,Cytochrome C,CYCS |
Human | E. coli |
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic... | |||
TMPY-04936 |
BCL2A1 Protein, Human, Recombinant (His)
BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 |
Human | E. coli |
B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der... | |||
TMPJ-00681 |
EDIL3 Protein, Human, Recombinant (His)
EGF-Like Repeats and Discoidin I-Like Domains 3,EDIL3 |
Human | HEK293 Cells |
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence a... | |||
TMPY-04417 |
DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)
DAPK,death-associated protein kinase 1,ROCO3 |
Human | Baculovirus Insect Cells |
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g... | |||
TMPY-01824 |
Caspase-14 Protein, Human, Recombinant (His)
caspase 14, apoptosis-related cysteine peptidase,ARCI12<... |
Human | E. coli |
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Casp... | |||
TMPY-01442 |
DMBT1 Protein, Human, Recombinant (His)
GP340,deleted in malignant brain tumors 1,muclin |
Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo... | |||
TMPJ-00850 |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Protein T1,suppression of tumorigenicity 2,Ly84,DER... |
Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2. | |||
TMPY-00891 |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
neuropilin 1,VEGF165R,CD304,NP1,Neuropilin-1,NRP,BDCA4 |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2. | |||
TMPY-02011 |
CD96 Protein, Human, Recombinant (His)
CD96 molecule,TACTILE |
Human | HEK293 Cells |
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2. | |||
TMPY-04113 |
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI... |
Human | E. coli |
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-01613 |
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
A630052E07Rik,OSF-2,Osf2,PLF,AI74... |
Mouse | HEK293 Cells |
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2. | |||
TMPY-01717 |
VEGF164 Protein, Mouse, Recombinant
vascular endothelial growth factor A,Vpf,Vegf,血管内皮生长因子 |
Mouse | Baculovirus Insect Cells |
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2. | |||
TMPY-02096 |
TACI Protein, Human, Recombinant (His)
RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor... |
Human | HEK293 Cells |
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2. | |||
TMPY-00341 |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2. | |||
TMPY-03795 |
EIF5A2 Protein, Human, Recombinant (His)
eIF5AII,eukaryotic translation initiation factor 5A2 |
Human | E. coli |
Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe... | |||
TMPY-06056 |
KRAS Protein, Human, Recombinant (G12D, His)
KRAS1,K-RAS4B,Kirsten rat sarcoma viral oncogene homolog,RAL... |
Human | E. coli |
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2. | |||
TMPY-00751 |
TrkB Protein, Human, Recombinant (His)
trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine kinase, rec... |
Human | HEK293 Cells |
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2. | |||
TMPY-01691 |
Clusterin Protein, Human, Recombinant (CLU34, His)
SGP-2,AAG4,KUB1,CLI,CLU2,TRPM2,AP... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2. | |||
TMPY-04844 |
BTN3A1 Protein, Human, Recombinant (His)
BTN3.1,butyrophilin subfamily 3 member A1,BTF5,BT3.1,CD2... |
Human | HEK293 Cells |
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2. | |||
TMPY-05288 |
PLGF/PGF Protein, Human, Recombinant (aa 19-149)
PLGF,PGFL,placental growth factor,D12S1900,SHGC-107... |
Human | E. coli |
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2. | |||
TMPY-02820 |
SDF-1 Protein, Human, Recombinant (isoform a)
SDF1,chemokine (C-X-C motif) ligand 12,IRH,SCYB1 |
Human | E. coli |
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2. | |||
TMPY-01935 |
c-Kit Protein, Human, Recombinant (His)
PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog... |
Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2. | |||
TMPY-04356 |
GSK3B Protein, Human, Recombinant (His)
glycogen synthase kinase 3 beta,glycogen synthase kinase 3 β |
Human | Baculovirus Insect Cells |
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2. | |||
TMPY-02500 |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)
Gp39,AW208766,Brp39,chitinase 3 like 1 |
Mouse | HEK293 Cells |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2. | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPY-01985 |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
FCGR2,FCGR21,CD32A,FCG2,... |
Human | HEK293 Cells |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2. | |||
TMPY-04644 |
PDGFB Protein, Human, Recombinant (His)
platelet-derived growth factor beta polypeptide,SSV,c-sis,SI... |
Human | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted... | |||
TMPY-05414 |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc)
D6H12S2489E,NKG2-D,killer cell le... |
Mouse | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2. | |||
TMPY-01871 |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)
interleukin 5 receptor, alpha,IL5R,CD125,CDw12<... |
Human | HEK293 Cells |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2. | |||
TMPY-02792 |
GDNF Protein, Human, Recombinant (HEK293)
HSCR3,ATF2,HFB1-GDNF,ATF1,glial cell derived neurot... |
Human | HEK293 Cells |
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2. | |||
TMPY-01888 |
KRAS Protein,Human, Recombinant (Q61H, His)
KRAS2,C-K-RAS,Kirsten rat sarcoma viral oncogene ho... |
Human | E. coli |
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2. | |||
TMPY-01359 |
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
IL1RL1,IL‑1 R4,DER4,ST2,IL33R,interleukin 1 recepto... |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2. | |||
TMPY-00747 |
Nectin-2 Protein, Human, Recombinant (His)
PVRR2,Nectin-2,poliovirus receptor-related... |
Human | HEK293 Cells |
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2. | |||
TMPY-05427 |
CD19 Protein, Human, Recombinant (hFc)
CVID3,B4,CD19 molecule |
Human | HEK293 Cells |
CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2. | |||
TMPJ-00335 |
TGFBR2 Protein, Mouse, Recombinant (His)
TGFR-2,TGF-beta type II receptor,Transforming growt... |
Mouse | HEK293 Cells |
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2. | |||
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