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Anti-Bcl-2 Antibody (9K951)

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货号 TMAB-03059

Anti-Bcl-2 Antibody (9K951) 是一种 Rabbit 抗体，靶向 Bcl-2。Anti-Bcl-2 Antibody (9K951) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Bcl-2 Antibody (9K951)

Anti-Bcl-2 Antibody (9K951)

一键复制产品信息
Rating icon 还可以
货号 TMAB-03059

Anti-Bcl-2 Antibody (9K951) 是一种 Rabbit 抗体，靶向 Bcl-2。Anti-Bcl-2 Antibody (9K951) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,395
5日内发货
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产品介绍

生物活性
产品描述
Anti-Bcl-2 Antibody (9K951) is a Rabbit antibody targeting Bcl-2. Anti-Bcl-2 Antibody (9K951) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
9K951
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:1000-5000; IHC-P: 1:200-500; IHC-Fr: 1:200-500; IF: 1:200-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
组织特异性Expressed in a variety of tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
研究背景The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).
抗原信息
免疫原
Recombinant Protein: human Bcl-2 protein
抗原种属
Human
基因名称
BCL2
基因ID
596
蛋白名称
Apoptosis regulator Bcl-2
Uniprot ID
P10415
功能
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
化学信息
分子量Theoretical: 26 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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