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Anti-BCL-XL Antibody (1J99) 是一种 Mouse 抗体,靶向 BCL-XL。Anti-BCL-XL Antibody (1J99) 可用于 ELISA, WB, IHC。
Anti-BCL-XL Antibody (1J99) 是一种 Mouse 抗体,靶向 BCL-XL。Anti-BCL-XL Antibody (1J99) 可用于 ELISA, WB, IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μg | ¥ 1,310 | 5日内发货 | |
100 μg | ¥ 2,185 | 5日内发货 |
产品描述 | Anti-BCL-XL Antibody (1J99) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (1J99) can be used in ELISA, WB, IHC. |
别名 | PPP1R52, bcl-xS, BCLXS, BCL-XL/S, bcl-xL, BCLXL, Bcl-X, BCLX, BCL2-like 1, BCL2L |
Ig Type | IgG1 |
克隆号 | 1J99 |
交叉反应 | Human |
验证活性 | 1. Immunohistochemical of paraffin-embedded Human endometrium tissue using TMAH-00110 at dilution of 1:200 2. Immunohistochemical of paraffin-embedded Human Colon cancer tissue using TMAH-00110 at dilution of 1:200 3. Western Blot -All lanes:Mouse anti BCL2L1 Monoclonal antibody at 1μg/ml -Lane 1:HepG2 whole cell lysate -Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution -Predicted band size:26,27,19kd -Observed band size:26KD |
应用 | |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
亚细胞定位 | [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. |
构建方式 | Hybridoma Monoclonal Antibody |
纯化方式 | Protein G purified |
性状 | Liquid |
缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
纯度 | >95% |
研究背景 | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein: Human Bcl-2-like Protein 1 Protein |
抗原种属 | Human |
基因ID | |
Uniprot ID | |
研究领域 | Cell Biology |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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