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Anti-Bad Antibody (4Z819)

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产品编号 TMAC-00365

别名 Proapoptotic BH3 Only Protein, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like protein 8, Bcl2-L-8, BCL2L8, Bcl-2-binding component 6, Bcl2 Like 8 Protein, Bcl2 binding protein, BCL2 binding component 6, Bcl2 Associated Death Promoter, BCL2 associated agonist of cell death, BCL2 antagonist of cell death protein, Bcl2 antagonist of cell death, Bcl XL/Bcl 2 Associated Death Promoter, BCL X Binding Protein, BCL X / BCL 2 Binding Protein, Bcl 2 Binding Component 6, Bcl 2 Antagonist of Cell Death, BBC6, BBC2, BBC 2, BAD_HUMAN, BAD, AI325008

Anti-Bad Antibody (4Z819) 是一种 Rabbit 抗体，靶向 Bad。Anti-Bad Antibody (4Z819) 可用于 FCM,ICC/IF,IHC,IP,WB。

Anti-Bad Antibody (4Z819)

Anti-Bad Antibody (4Z819)

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产品编号 TMAC-00365 别名 Proapoptotic BH3 Only Protein, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like protein 8, Bcl2-L-8, BCL2L8, Bcl-2-binding component 6, Bcl2 Like 8 Protein, Bcl2 binding protein, BCL2 binding component 6, Bcl2 Associated Death Promoter, BCL2 associated agonist of cell death, BCL2 antagonist of cell death protein, Bcl2 antagonist of cell death, Bcl XL/Bcl 2 Associated Death Promoter, BCL X Binding Protein, BCL X / BCL 2 Binding Protein, Bcl 2 Binding Component 6, Bcl 2 Antagonist of Cell Death, BBC6, BBC2, BBC 2, BAD_HUMAN, BAD, AI325008

Anti-Bad Antibody (4Z819) 是一种 Rabbit 抗体，靶向 Bad。Anti-Bad Antibody (4Z819) 可用于 FCM,ICC/IF,IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Bad Antibody (4Z819) is a Rabbit antibody targeting Bad. Anti-Bad Antibody (4Z819) can be used in FCM,ICC/IF,IHC,IP,WB.
别名Proapoptotic BH3 Only Protein, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like protein 8, Bcl2-L-8, BCL2L8, Bcl-2-binding component 6, Bcl2 Like 8 Protein, Bcl2 binding protein, BCL2 binding component 6, Bcl2 Associated Death Promoter, BCL2 associated agonist of cell death, BCL2 antagonist of cell death protein, Bcl2 antagonist of cell death, Bcl XL/Bcl 2 Associated Death Promoter, BCL X Binding Protein, BCL X / BCL 2 Binding Protein, Bcl 2 Binding Component 6, Bcl 2 Antagonist of Cell Death, BBC6, BBC2, BBC 2, BAD_HUMAN, BAD, AI325008
Ig Type
IgG
克隆号
4Z819
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Bad on MCF-7 cell lysates using anti-Bad antibody at 1/500 dilution.
2. ICC staining Bad in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining Bad in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. Flow cytometric analysis of Hela cells with Bad antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
verifiedActivityverifiedActivityverifiedActivityverifiedActivity
应用FCMICC/IFIHCIPWB
推荐剂量
WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:10-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. A protein designated Bad exhibits homology to Bcl-2 limited to the BH1 and BH2 domains. Bad functions to dimerize with Bcl-xL and with Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2. Dimerization of Bad with Bcl-xL results in displacement of Bax from Bcl-xL:Bax complexes thereby causing restoration of Bax-mediated apoptosis.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q92934
化学信息
分子量Theoretical: 23 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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