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Anti-Bcl-2 Antibody (7L839)

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货号 TMAB-03054

Anti-Bcl-2 Antibody (7L839) 是一种 Mouse 抗体，靶向 Bcl-2。Anti-Bcl-2 Antibody (7L839) 可用于 WB,ICC/IF,FCM。

Anti-Bcl-2 Antibody (7L839)

Anti-Bcl-2 Antibody (7L839)

一键复制产品信息
Rating icon 还可以
货号 TMAB-03054

Anti-Bcl-2 Antibody (7L839) 是一种 Mouse 抗体，靶向 Bcl-2。Anti-Bcl-2 Antibody (7L839) 可用于 WB,ICC/IF,FCM。

规格价格库存数量
200 μg
¥ 5,585
5日内发货
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Bcl-2 Antibody (7L839) is a Mouse antibody targeting Bcl-2. Anti-Bcl-2 Antibody (7L839) can be used in WB,ICC/IF,FCM.
Ig Type
IgG1
克隆号
7L839
反应种属
Human
应用WBICC/IFFCM
推荐剂量
WB: 1:1000-5000; ICC/IF: 1:100-500; FCM: 1μg/Test
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
组织特异性Expressed in a variety of tissues.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).
抗原信息
免疫原
Recombinant Protein: human Bcl-2 protein
抗原种属
Human
基因名称
BCL2
基因ID
596
蛋白名称
Apoptosis regulator Bcl-2
Uniprot ID
P10415
功能
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
化学信息
分子量Theoretical: 26 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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