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Anti-BCL2 Antibody (5A692)
还可以产品编号 TMAY-00066
Anti-BCL2 Antibody (5A692) 是一种 Rabbit 抗体，靶向 BCL2。Anti-BCL2 Antibody (5A692) 可用于 IHC-P,FCM。
Anti-BCL2 Antibody (5A692)
Anti-BCL2 Antibody (5A692)
还可以产品编号 TMAY-00066
Anti-BCL2 Antibody (5A692) 是一种 Rabbit 抗体，靶向 BCL2。Anti-BCL2 Antibody (5A692) 可用于 IHC-P,FCM。
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抗原信息
| 产品描述 | Anti-BCL2 Antibody (5A692) is a Rabbit antibody targeting BCL2. Anti-BCL2 Antibody (5A692) can be used in IHC-P,FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5A692 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human BCL-2 in human tonsil with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human BCL-2 in human sarcoma with rabbit monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). 3. Flow cytometric analysis of Human BCL2 expression on Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human BCL2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | IHC-P,FCM |
| 推荐剂量 | IHC-P: 1:250-1:1000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the N-terminus of the Human Bcl-2. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes. It is expressed in a variety of tissues. BCL2 blocks the apoptotic death of some cells such as lymphocytes. It also regulates cell death by controlling the mitochondrial membrane permeability and inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PerCP/FITC/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | A synthetic peptide corresponding to the N-terminus of the Human Bcl-2. |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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