pdeδ

K-Ras-PDEδ-IN-1 是新型的 K-Ras-PDEδ 抑制剂，它能够以低纳摩尔Kd8 nM 与 PDEδ 的法尼基结合袋竞争性结合。

Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.

Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.

Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.

PDE7-IN-2 是磷酸二酯酶 7 (IC50 = 2.1 µM) 的抑制剂，可用于帕金森病研究。

PDE IV-IN-1 是一种有效的磷酸二酯酶4 (PDE4)抑制剂，具有抗炎活性，可用于治疗哮喘，慢性阻塞性肺病和其他炎症性疾病，是研究抑郁症的潜在化合物。

PDE9-IN-1 是一种选择性和口服生物可利用的 PDE9A 抑制剂（IC50 为 8.7 nM）。

PDE4B-IN-2 (A 33) 是一种具有口服活性，选择性 PDE4B 抑制剂，IC50 为 15 nM。PDE4B-IN-2 抑制 PDE4D (IC50=1.7 µM)。PDE4B-IN-2 表现出有效的抗炎作用。

PDE5-IN-9对Phosphodiesterase PDE1c 具有抑制作用，可用来治疗高血压、心力衰竭、心肌梗塞、肾衰竭、哮喘、支气管炎和痴呆。

PDE5-IN-6c is a potent and selective inhibitor of PDE5A1.

PDE-I2 is a parasite schizogony inhibitor.

PDE5-IN-42 is a selective inhibitor of second-generation phosphodiesterase type 5 (PDE5).

PDE1-IN-2 is an PDE1 inhibitor(PDE1C, PDE1B and PDE1A with IC50 values of 6, 140 and 164 nM, respectvely).

PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of pulmonary diseases.

PDE1-IN-3 is a selective inhibitor of human phosphodiesterase 1 (PDE1).

PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.

PDE4 inhibitor intermediate 1 is a PDE4 inhibitor synthesis intermediate.

PDE10A-IN-8 is a potent inhibitor of PDE10A.

PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC 50 value of 1.3 nM.

PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP) cAMP-response element-binding protein (CREB) pathway.

PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)

PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity.

PDE12-IN-3 is an inhibitor of phosphodiesterase 12 (PDE12) (pXC50 of 7.68),with antiviral activity.

PDE-9 inhibitor is used for treatment neurodegenerative diseases.