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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PDE4A Polyclonal Antibody

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货号 TMAB-10109

Anti-PDE4A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PDE4A。Anti-PDE4A Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-PDE4A Polyclonal Antibody

Anti-PDE4A Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-10109

Anti-PDE4A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PDE4A。Anti-PDE4A Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-PDE4A Polyclonal Antibody is a Rabbit antibody targeting PDE4A. Anti-PDE4A Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Pig,Cow,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Cytoplasm, perinuclear region. Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane. Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes. Isoform 6: Cytoplasm, perinuclear region. Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.
组织特异性Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. In brain, more than 90% of cAMP formed by the stimulation of GPCRs is hydrolyzed by PDE4 enzymes. PDE4 enzymes are also important molecular targets for a variety of therapeutic agents like antidepressants, anti-asthmatics, and anti-inflammatory drugs. PDE4 family comprises 4 genes (PDE4A, B, C and D); each exhibiting multiple isozymes due to alternate splicing that leads to a larger number of distinct PDE4 variants. Members of the PDE4 family are regulated/activated by phosphorylation/dephosphorylation by cAMP-dependent protein kinase A and phosphatases. Protein-protein interactions and cellular trafficking of PDE4A enzymes play an important role in cAMP compartmentalization and cAMP-dependent signaling. In brain members of the PDE4A, B and D family are associated with GPCRs (adrenergic and dopaminergic) signaling. There are 5 isoforms.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PDE4A
抗原种属
Human
基因名称
PDE4A
基因ID
5141
蛋白名称
cAMP-specific 3', 5'-cyclic phosphodiesterase 4A
Uniprot ID
P27815
功能
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
化学信息
分子量Theoretical: 98 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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