Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物,是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化,破坏预先形成的AB17-42三聚体,并结合到磷酸二酯酶5A (PDE5A)的催化位点,可以调节机体免疫系统,影响细胞的氧化状态,改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂, 具有研究糖尿病等慢性炎症性疾病的潜力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 217 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 195 | 待询 |
产品描述 | Fulvic Acid is a natural product of humus produced by microorganisms in soil, sediment or aquatic environments. Fulvic acid is a phenolic acid and fungal metabolite isolated from Penicillium for the first time. Fulvic Acid inhibits the dimerization of amyloid b (17-42) (AB17-42), destroys the pre-formed trimer of AB17-42, and binds to the catalytic site of phosphodiesterase 5A (PDE5A), which can regulate the body's immune system, affect the oxidation state of cells, and improve gastrointestinal function. Fulvic Acid can be used as an oxidant or reducing agent and has the potential to study chronic inflammatory diseases such as diabetes. |
体外活性 | Fulvic acid (15 mg/L) enhanced growth and achieved the highest EPA content (13.9%) in the evolved diatom. Fulvic acid enhanced antioxidant potential and unprecedently governed the expression of PUFA and lipid biosynthetic genes. This investigation demonstrates the efficacy of adaptive evolution empowered by fulvic acid.[1] Embryogenic cell masses (ECM) of Abies cephalonica were grown on proliferation media in the presence and absence of fulvic acid (FA), FA increased the proliferation rate, especially during the early sampling days, and the percentage of PEM in their advanced developmental stage. During the maturation phase, fulvic matter also induced a delay in somatic embryo formation. The structure-activity relationship observed here suggests that the influence of FA on ECM may be attributed to specific bioactive molecules that are preferentially released from the FA loose superstructure.[2] |
分子量 | 308.24 |
分子式 | C14H12O8 |
CAS No. | 479-66-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.08 mg/mL (10 mM), Sonication is recommended.
Methanol: Soluble
Chloroform: Soluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.2442 mL | 16.2211 mL | 32.4423 mL | 81.1056 mL |
5 mM | 0.6488 mL | 3.2442 mL | 6.4885 mL | 16.2211 mL | |
10 mM | 0.3244 mL | 1.6221 mL | 3.2442 mL | 8.1106 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fulvic Acid 479-66-3 Metabolism oxidation-reduction PDE Antioxidant Inhibitor inhibitor inhibit