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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PDE5A Polyclonal Antibody

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货号 TMAB-10113

Anti-PDE5A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PDE5A。Anti-PDE5A Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

Anti-PDE5A Polyclonal Antibody

Anti-PDE5A Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10113

Anti-PDE5A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PDE5A。Anti-PDE5A Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-PDE5A Polyclonal Antibody is a Rabbit antibody targeting PDE5A. Anti-PDE5A Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig)
应用WBIHC-PIHC-FrIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 0.2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The cGMP specific phosphodiesterase type 5A (PDE5A) family is comprised of 2 genes (PDE5A and PDE5B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. The PDE5 is highly expressed in aorta and lungs, intestine, kidney adrenal gland cerebellum and cerebrum. In cerebellum the PDE5 is highly expressed during neonatal development in Purkinge cells layer. The PDE5 is also abundant in vascular smooth muscle regulating cGMP levels and vascular smooth muscle tonicity. In corpus cavernosum inhibition of PDE5 by sildenafil corrects erectile dysfunctions. The nitric oxide donor sodium notropurside (SNP) stimulate PDE5 activity by cGMP dependent kinase phosphorylation. PDE5A1 has 875 amino acids (99.5 kDa). The amino terminal 142 amino acid of the PDE5 gene showed no sequence homology with other PDEs and also contained serine 92 that is phosphorylated by cGMP kinases.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PDE5A
抗原种属
Human
基因名称
PDE5A
基因ID
8654
蛋白名称
cGMP-specific 3', 5'-cyclic phosphodiesterase
功能
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
化学信息
分子量Theoretical: 100 kDa.
颜色Transparent
物理性状Liquid
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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