epi

Epirubicin (4'-Epidoxorubicin) 是一种蒽环类抗生素，作为拓扑异构酶 II (Topoisomerase II) 抑制剂发挥作用。它通过嵌入 DNA 碱基对之间，抑制 DNA 复制和转录，并诱导 DNA 断裂，从而导致癌细胞凋亡。Epirubicin 广泛用于治疗乳腺癌、胃癌、肺癌和淋巴瘤等多种恶性肿瘤。

EPI-589, a quinone derivative and oxidoreductase enzyme inhibitor, is considered safe and well tolerated, showing promise for the treatment of amyotrophic lateral sclerosis (ALS).

8-epi-Chlorajapolide F 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124075。

3-Epi-beta-amyrin 是一种从植物中分离到的萜类天然产物。

3-Epi-alpha-amyrin 是一种从植物中分离到的萜类天然产物。

15-Epi-Danshenol-A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125334。

Epi-Cryptoacetalide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126054。

7-Epi-paradisiol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131585。

7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a docetaxel impurity identified by HPLC.

epi-D-Captopril (epi-D-SQ 14225) 是一种Captopril的立体异构体，也是金属 β-内酰胺酶 (MBLs) 的抑制剂。其对NDM-1、IMP-1和VIM-2的IC50值分别为64 μM、173 μM和5.5 μM。epi-D-Captopril 具有在MBLs相关耐药菌感染领域进行研究的潜力。

4'-epi-Daunorubicin是Epirubicin的半合成前体，是一种抗肿瘤剂。

6-epi-COTC 是一种链霉菌代谢物的非对映异构体，具有抗癌活性。

4-Demethoxy-7,9-di-epi-daunorubicin 是 Daunorubicin 的一种衍生物，属于蒽环类抗生素 (antibiotics)。它能够与小牛胸腺 DNA 结合，并形成与堆叠 DNA 碱基对的复合物。该化合物可抑制原核生物的核酸聚合酶，包括大肠杆菌 DNA 聚合酶 I (DNA polymerase I) 和 RNA 聚合酶 (RNA polymerase)。4-Demethoxy-7,9-di-epi-daunorubicin 被用于癌症和感染研究。

3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017)

Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline.

1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion[1].

7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control.

Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.

5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.

EPI-7170 是一种 ralaniten 类似物，是雄激素受体 N 端结构域 (androgen receptor N-terminal structural domain) 的有效拮抗剂，能够阻断全长 AR (FL-AR) 和 AR 剪接变体 (AR-Vs) 的转录活性。 EPI-7170 对 enzalutamide 耐药的去势抵抗性前列腺癌 (CRPC) 表现出抗肿瘤活性。

EPI-001 是一种选择性雄激素受体 (AR) 的抑制剂，靶向 AR 的反式激活单元 5，可抑制 AR 氨基末端结构域的反式激活，IC50值约为 6 μM。它也是一种选择性的PPARγ调节剂，对去势抵抗性前列腺癌具有活性。

6-trans-12-epi-Leukotriene B4 是一种花生四烯酸代谢物，是一种有效的抗炎剂。

3-epi-Vitamin D3 (Epicholecalciferol) 是维生素 D3 类似物，是一种Hedgehogpathway 抑制剂，在U87MG 细胞中测定的IC50为 39.2 μM。

7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) 是一种与ERβ结合的内源性雄激素衍生物，具有抗炎和神经保护特性。该化合物来源于dehydroepiandrosterone。