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Progranulin Protein, Human, Recombinant (His)

Progranulin Protein, Human, Recombinant (His)

产品编号 TMPY-00978
别名: PGRN, PCDGF, CLN11, Granulin, GP88, GEP, Granulin Precursor, Progranulin, PEPI

Progranulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.2 kDa and the accession number is P28799-1.

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Progranulin Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,430 现货
200 μg ¥ 6,050 5日内发货
500 μg ¥ 12,770 5日内发货
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产品目录号及名称: Progranulin Protein, Human, Recombinant (His) (TMPY-00978)
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生物活性 Testing in progress
产品描述 Progranulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.2 kDa and the accession number is P28799-1.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P28799-1
别名 PGRN, PCDGF, CLN11, Granulin, GP88, GEP, Granulin Precursor, Progranulin, PEPI
蛋白构建 Human Progranulin (NP_002078.1) (Met 1-Leu 593) with a C-terminal polyhistidine tag
蛋白纯度 > 95 % as determined by SDS-PAGE

TargetMol

分子量 63.2 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

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Keywords

Progranulin Protein, Human, Recombinant (His) PGRN CLN-11 PCDGF CLN11 Granulin GP88 GEP Granulin Precursor CLN 11 GP-88 GP 88 Progranulin PEPI recombinant recombinant-proteins proteins protein

 

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