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Anti-CDH1 Antibody (1P971)
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产品编号 TMAH-00245
别名 UVO, LCAM, E-Cadherin, E-cad, ECAD, CDHE, CDH1, CD324, cadherin 1, type 1, E-cadherin (epithelial), Arc-1
Anti-CDH1 Antibody (1P971) 是一种抗体，靶向 CDH1。Anti-CDH1 Antibody (1P971) 可用于 ELISA, IHC。
Anti-CDH1 Antibody (1P971)
Anti-CDH1 Antibody (1P971)
还可以产品编号 TMAH-00245 别名 UVO, LCAM, E-Cadherin, E-cad, ECAD, CDHE, CDH1, CD324, cadherin 1, type 1, E-cadherin (epithelial), Arc-1
Anti-CDH1 Antibody (1P971) 是一种抗体，靶向 CDH1。Anti-CDH1 Antibody (1P971) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CDH1 Antibody (1P971) is an antibody targeting CDH1. Anti-CDH1 Antibody (1P971) can be used in ELISA, IHC. |
| 别名 | UVO, LCAM, E-Cadherin, E-cad, ECAD, CDHE, CDH1, CD324, cadherin 1, type 1, E-cadherin (epithelial), Arc-1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 1P971 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00245 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human E Cadherin |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Cancer, Developmental biology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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