规格

价格

库存

数量

1 mg

¥ 347

现货

5 mg

¥ 828

现货

10 mg

¥ 1,320

现货

25 mg

¥ 2,650

现货

50 mg

¥ 4,130

现货

100 mg

¥ 5,880

现货

200 mg

¥ 7,950

现货

1 mL x 10 mM (in DMSO)

¥ 719

现货

生物活性

产品描述	Ralaniten (EPI-002) is a potent, specific, and orally active antagonist of the androgen receptor N-terminal structural domain (AR-NTD).Ralaniten inhibits AR transcriptional activity with an IC50 value of 7.4 μM.Ralanites have anticancer activity and can be used to study desmoplasia-resistant prostate cancer (CRPC).
靶点活性	AR-NTD:7.4 μM (IC50)
体外活性	Ralaniten(5-35 μM; 2-3 days) reduces AR-dependent proliferation of LNCaP cells and has no effect on the viability of PC3 human prostate cancer cells that do not express functional AR.[1] Ralaniten (10-35 μM; 4 hours) inhibits forskolin-induced transactivation of the AR N-terminal domain (NTD) in LNCaP cells.[1]
体内活性	Ralaniten (100 mg/kg; taken orally twice daily for 28 days; Male NOD-SCID mice bearing subcutaneous tumors were castrated) inhibits VCaP tumor growth in castrated mice.[1]
别名	EPI-002

化学信息

分子量	394.89
分子式	C₂₁H₂₇ClO₅
CAS No.	1203490-23-6
Smiles	CC(C)(c1ccc(OC[C@H](O)CO)cc1)c1ccc(OC[C@H](O)CCl)cc1
密度	1.228 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 90 mg/mL (227.91 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 3.3 mg/mL (8.36 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO