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EGFR Protein, Rat, Recombinant (His)

产品编号 TMPY-02958

EGFR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is E7CXR8.

EGFR Protein, Rat, Recombinant (His)

产品编号 TMPY-02958

EGFR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is E7CXR8.

规格	价格	库存	数量
100 μg	¥ 3,820	5日内发货

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产品信息

生物活性	1. Measured by its ability to bind recombinant human EGF-Fc in a functional ELISA. 2. Measured by its ability to bind recombinant mouse EGF-Fc in a functional ELISA.
产品描述	EGFR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is E7CXR8.
种属	Rat
表达系统	HEK293 Cells
标签	C-His
蛋白编号	E7CXR8
别名	epidermal growth factor receptor
蛋白构建	A DNA sequence encoding the rat EGFR (E7CXR8) (Met1-Ser646) was expressed, fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Leu 25
蛋白纯度	≥ 98 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	70.7 kDa (predicted); 93-110 kDa (reducing condition, due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy