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EGFR Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-02675

别名: Erbb, AI552599, wa-2, 9030024J15Rik, Errp, wa2, Errb1, Wa5, epidermal growth factor receptor

EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.

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EGFR Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 24,900		5日内发货

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参考文献

生物活性	Measured by its ability to bind human EGF in a functional ELISA.
产品描述	EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q01279
别名	Erbb, AI552599, wa-2, 9030024J15Rik, Errp, wa2, Errb1, Wa5, epidermal growth factor receptor
蛋白构建	The extracellular domain of Mouse EGFR (Q01279) (Met 1-Ser 647) was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	96 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25. 2. Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48. 3. Yarden, Y.,et al.(2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.

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Keywords

EGFR Protein, Mouse, Recombinant (hFc) Erbb AI552599 wa-2 9030024J15Rik Errp wa2 Errb1 AI-552599 Wa5 epidermal growth factor receptor AI 552599 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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