Anti-EGF Antibody (2R454)

Name: Anti-EGF Antibody (2R454)
Brand: TargetMol
SKU: TMAY-03662
Rating: 4.5 (1 reviews)

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产品编号 TMAY-03662

Anti-EGF Antibody (2R454) 是一种 Mouse 抗体，靶向 EGF。Anti-EGF Antibody (2R454) 可用于 ELISA。

Anti-EGF Antibody (2R454)

还可以

产品编号 TMAY-03662

Anti-EGF Antibody (2R454) 是一种 Mouse 抗体，靶向 EGF。Anti-EGF Antibody (2R454) 可用于 ELISA。

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产品描述	Anti-EGF Antibody (2R454) is a Mouse antibody targeting EGF. Anti-EGF Antibody (2R454) can be used in ELISA.
Ig Type	Monoclonal Mouse IgG1
克隆号	2R454
交叉反应	Canine
应用	ELISA
推荐剂量	ELISA: 1:1000-1:2000
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Canine EGF / Epidermal Growth Factor ( TMPY-02539; Q9BEA0; Asn973-Arg1024). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Canine EGF / Epidermal Growth Factor Protein (TMPY-02539)
抗原种属	Canine

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.