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Anti-Progranulin Antibody-HRP (7I314)
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产品编号 TMAY-01231H
别名 Pgrn, Granulin Precursor, epithelin
Anti-Progranulin Antibody-HRP (7I314) 是一种 HRP-conjugated Mouse 抗体，靶向 Progranulin。Anti-Progranulin Antibody-HRP (7I314) 可用于 ELISA。
Anti-Progranulin Antibody-HRP (7I314)
331 Anti-Progranulin Antibody-HRP (7I314)
还可以产品编号 TMAY-01231H 别名 Pgrn, Granulin Precursor, epithelin
Anti-Progranulin Antibody-HRP (7I314) 是一种 HRP-conjugated Mouse 抗体，靶向 Progranulin。Anti-Progranulin Antibody-HRP (7I314) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | ¥ 790 | 5日内发货 | |
| 100 μg | ¥ 2,495 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Progranulin Antibody-HRP (7I314) is a HRP-conjugated Mouse antibody targeting Progranulin. Anti-Progranulin Antibody-HRP (7I314) can be used in ELISA. |
| 别名 | Pgrn, Granulin Precursor, epithelin |
| Ig Type | Mouse IgG1 |
| 克隆号 | 7I314 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granulin / GRN (rhGRN; TMPY-00978; Met 1-Leu 593; NP_002078.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat. |
| 偶联 | HRP |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Protein: Human Granulin protein (TMPY-00978) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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