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EGFR Protein, Human, Recombinant (Isoform Viii, hFc)

产品编号 TMPY-05258

别名: NISBD2, epidermal growth factor receptor, ERBB, PIG61, mENA, ERBB1, HER1

EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1.

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EGFR Protein, Human, Recombinant (Isoform Viii, hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 2,530		5日内发货
1 mg	￥ 24,900		5日内发货

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参考文献

生物活性	1. Immobilized EGF Protein, Human, Recombinant (ECD), HPLC-verified at 2 μg/mL (100 μL/well) can bind EGFR Protein, Human, Recombinant (Isoform Viii, hFc Tag) in functional ELISA. 2. Immobilized Anti-EGFR(MK)-IgG1 Antibody (Cetuximab) at 2 μg/mL (100 μL/well) can bind EGFR Protein, Human, Recombinant (Isoform Viii, hFc Tag), the EC50 is 4-13 ng/mL.
产品描述	EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	C-hFc
蛋白编号	NP_001333870.1
别名	NISBD2, epidermal growth factor receptor, ERBB, PIG61, mENA, ERBB1, HER1
蛋白构建	The Human EGFR (NP_001333870.1) (Met1-Lys375) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	65.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM Glycine, 10 mM NaCl, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25. 2. Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48. 3. Yarden, Y.,et al.(2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.

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Keywords

EGFR Protein, Human, Recombinant (Isoform Viii, hFc) HER-1 PIG 61 NISBD2 NISBD-2 epidermal growth factor receptor ERBB PIG-61 NISBD 2 PIG61 mENA HER 1 ERBB1 HER1 ERBB-1 ERBB 1 recombinant recombinant-proteins proteins protein

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