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Anti-EGFR Antibody (6Z678)
还可以产品编号 TMAY-00023
别名 PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor
Anti-EGFR Antibody (6Z678) 是一种 Mouse 抗体，靶向 EGFR。Anti-EGFR Antibody (6Z678) 可用于 IHC-P。
Anti-EGFR Antibody (6Z678)
Anti-EGFR Antibody (6Z678)
还可以产品编号 TMAY-00023 别名 PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor
Anti-EGFR Antibody (6Z678) 是一种 Mouse 抗体，靶向 EGFR。Anti-EGFR Antibody (6Z678) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-EGFR Antibody (6Z678) is a Mouse antibody targeting EGFR. Anti-EGFR Antibody (6Z678) can be used in IHC-P. |
| 别名 | PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6Z678 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human EGFR in human rectal carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human EGFR in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast. 3. Immunochemical staining of human EGFR in human esophageal carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; TMPY-04529; NP_005219; Met668-Ala1210). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human EGFR / HER1 / ErbB1 protein (TMPY-04529) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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