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顶部生物活性储存和溶解信息计算器

Anti-PINK1 Antibody (1K285)

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产品编号 TMAB-01541
别名 Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK

Anti-PINK1 Antibody (1K285) 是一种 Mouse 抗体，靶向 PINK1。Anti-PINK1 Antibody (1K285) 可用于 WB。

Anti-PINK1 Antibody (1K285)

Anti-PINK1 Antibody (1K285)

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Rating icon 还可以
产品编号 TMAB-01541 别名 Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK

Anti-PINK1 Antibody (1K285) 是一种 Mouse 抗体，靶向 PINK1。Anti-PINK1 Antibody (1K285) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,575
5日内发货
100 μL
¥ 2,485
5日内发货
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浓度:1.0 mg/mL
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产品介绍

生物活性
产品描述
Anti-PINK1 Antibody (1K285) is a Mouse antibody targeting PINK1. Anti-PINK1 Antibody (1K285) can be used in WB.
别名Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK
Ig Type
IgG
克隆号
1K285
交叉反应
Human
验证活性
All Lanes: Anti-Pink1 (115-213) at 1:4000 dilution
Lane 1: A431 whole cell lysate
Lane 2: Mouse brain lysate
Lysates/proteins at 20 μg per Lane.
Secondary: Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size: 63 kDa Blocking/Dilution
buffer: 5% NFDM/TBST.
verifiedActivity
应用WB
推荐剂量
WB: 1:200-1000
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol.
组织特异性Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
Recombinant Protein: human PINK1 protein
抗原种属
Human
基因名称
PINK1
基因ID
65018
蛋白名称
Serine/threonine-protein kinase PINK1, mitochondrial
Uniprot ID
Q9BXM7
研究领域
Cardiac metabolism,Mitochondrial markers,Mitophagy fission and fusion,Neurodegenerative disease,Parkinson's disease,Mitochondrial,Other Kinases
功能
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN . Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 . Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form . Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).
化学信息
分子量Theoretical: 63 kDa.
颜色Transparent
物理性状Liquid
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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