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Anti-EGFR Antibody-APC (5D853)
还可以产品编号 TMAY-00022A
Anti-EGFR Antibody-APC (5D853) 是一种 APC-conjugated Mouse 抗体，靶向 EGFR。Anti-EGFR Antibody-APC (5D853) 可用于 FCM。
Anti-EGFR Antibody-APC (5D853)
Anti-EGFR Antibody-APC (5D853)
还可以产品编号 TMAY-00022A
Anti-EGFR Antibody-APC (5D853) 是一种 APC-conjugated Mouse 抗体，靶向 EGFR。Anti-EGFR Antibody-APC (5D853) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-EGFR Antibody-APC (5D853) is a APC-conjugated Mouse antibody targeting EGFR. Anti-EGFR Antibody-APC (5D853) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5D853 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of EGFR expression on human A431 cells. |
| 应用 | FCM |
| 推荐剂量 | 1 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; TMPY-00742; NP_005219; Met1-Ser645) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/Biotin/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human EGFR / HER1 / ErbB1 protein (TMPY-00742) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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