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Anti-Progranulin Antibody (7R706)

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Anti-Progranulin Antibody (7R706)
产品编号 TMAY-03266
别名 Pgrn, Granulin Precursor, epithelin

Anti-Progranulin Antibody (7R706) 是一种 Rabbit 抗体，靶向 Progranulin。Anti-Progranulin Antibody (7R706) 可用于 ELISA。

Anti-Progranulin Antibody (7R706)
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Anti-Progranulin Antibody (7R706)

Rating icon 还可以
Anti-Progranulin Antibody (7R706)
产品编号 TMAY-03266 别名 Pgrn, Granulin Precursor, epithelin

Anti-Progranulin Antibody (7R706) 是一种 Rabbit 抗体，靶向 Progranulin。Anti-Progranulin Antibody (7R706) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 2,279
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产品介绍

生物活性
产品描述
Anti-Progranulin Antibody (7R706) is a Rabbit antibody targeting Progranulin. Anti-Progranulin Antibody (7R706) can be used in ELISA.
别名Pgrn, Granulin Precursor, epithelin
Ig Type
Rabbit IgG
克隆号
7R706
交叉反应
Mouse
应用
ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Granulin / Progranulin / GRN (rM Granulin / Progranulin / GRN; TMPY-01435; NP_032201.2; Met 1-Leu 589).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse Granulin / Progranulin / GRN protein (TMPY-01435)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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