GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins. It exhibits high binding affinities to both BRD3 BD1 and BRD3 BD2, with K i values of 11.97 nM and 2.35 nM, respectively. This compound is utilized in cancer research [1].

GXF-111（化合物24）与BRD3 BD1和BRD3 BD2结合的亲和力显著，其K i 值分别为11.97 nM和2.35 nM [1]。在MV4-11和MM.1S细胞系中，GXF-111展现出明显的细胞活性，IC 50值分别为6.31 nM和95.2 nM [1]。此外，GXF-111（2, 10 nM; 24 h）能有效抑制MM.1S细胞中BET家族蛋白，从而抑制细胞生长 [1]。经过4天的处理，GXF-111在七种人类癌细胞系中显示出抗增殖活性，其IC 50 值范围从6.31 nM至17.25 μM [1]。