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TNF

TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T2434 LY 303511
化合物LY 303511
154447-38-8 99.91%
LY303511 是 LY294002 的结构类似物,可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性,还可逆地阻断 MIN6 胰岛瘤细胞中的K+电流,IC50为64.6±9.1 μM。
T30531 BMS-561392
化合物BMS-561392
611227-74-8 99.16%
BMS-561392 (DPC333)是一种肿瘤坏死因子-α(TNF-α)转化酶抑制剂。
TN2180 Sappanchalcone
化合物Sappanchalcone
94344-54-4 97.00%
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
T3426 Bacoside A
假马齿苋皂素A
11028-00-5
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotect...
TN4592 Murrangatin
化合物 TN4592
37126-91-3 98%
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN3635 Chlojaponilactone B
化合物 TN3635
1449382-91-5 98%
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN4938 Samidin
化合物 TN4938
477-33-8 98%
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
T5S0313 Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside
甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷
199796-12-8 98%
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells again...
TN5164 Trans-Hinokiresinol
化合物 TN5164
17676-24-3 98%
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
TN1681 Gentianine
秦艽甲素
439-89-4 98%
Gentianine 是一种有效的 Swertiamarin 衍生物,具有抗糖尿病、抗精神病、抗炎、降血压、利尿等作用,具有被开发成一种安全的降压药物的潜力。
TN4038 Eupatolide
泽兰内酯
6750-25-0 98%
Eupatolide 是从 Inula japonica 的花中分离出来的,具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
TN3587 Capillarisin
化合物 TN3587
56365-38-9 98%
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN5147 Tilifodiolide
化合物 TN5147
126724-95-6 98%
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
TMA1777 Hydrangenol 8-O-glucoside
化合物 TMA1777
67600-94-6 98%
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN3410 Anatabine
化合物 TN3410
581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN3452 Arteannuin M
化合物 TN3452
207446-90-0 98%
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN4429 Leucodin
化合物 TN4429
17946-87-1 98%
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosamini...
TN1890 Lupeol acetate
乙酸羽扇醇酯
1617-68-1 98%
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
TN5278 Zederone
化合物 TN5278
7727-79-9 98%
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN2974 3-O-Methylquercetin tetraacetate
化合物 TN2974
1486-69-7 98%
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
LY 303511
T2434
LY303511 是 LY294002 的结构类似物,可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性,还可逆地阻断 MIN6 胰岛瘤细胞中的K+电流,IC50为64.6±9.1 μM。
BMS-561392
T30531
BMS-561392 (DPC333)是一种肿瘤坏死因子-α(TNF-α)转化酶抑制剂。
Sappanchalcone
TN2180
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
Bacoside A
T3426
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotect...
Murrangatin
TN4592
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
Chlojaponilactone B
TN3635
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
Samidin
TN4938
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside
T5S0313
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells again...
trans-Hinokiresinol
TN5164
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
Gentianine
TN1681
Gentianine 是一种有效的 Swertiamarin 衍生物,具有抗糖尿病、抗精神病、抗炎、降血压、利尿等作用,具有被开发成一种安全的降压药物的潜力。
Eupatolide
TN4038
Eupatolide 是从 Inula japonica 的花中分离出来的,具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Tilifodiolide
TN5147
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
Hydrangenol 8-O-glucoside
TMA1777
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Arteannuin M
TN3452
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
Leucodin
TN4429
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosamini...
Lupeol acetate
TN1890
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the co...
Zederone
TN5278
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
3-O-Methylquercetin tetraacetate
TN2974
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
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