Name: Anti-inflammatory agent 91
Brand: TargetMol
SKU: T89600
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	Anti-inflammatory agent 91 (Compound 4o) is a chemical compound known for its efficacy in reducing inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. It is utilized in research to study its potential in ameliorating skin inflammation associated with psoriasis.
体外活性	Anti-inflammatory agent 91(Compound 4o)(10-80 μM; 24 h)对 HaCaT 细胞活力无明显影响.在 LPS (1 μg/mL; 24 h) 诱导的 RAW264.7 和 HaCaT 细胞模型中,Anti-inflammatory agent 91在 (10-40 μM; 2 h) 范围内显著抑制 NO (IC 50 = 19.5 μM)、TNF-α与 IL-6 (仅限RAW264.7)以及 IL-17A (仅限HaCaT),显示出其抗炎效果.
体内活性	抗炎药物91(Compound 4o)(25-100 mg/kg;局部涂抹,每日一次,持续5天)在由咪喹莫特诱发的银屑病小鼠模型中,通过抑制炎症相关细胞因子显著改善了银屑病症状.

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Anti-inflammatory agent 91