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P450

P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
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Cat. No. Product Name CAS No. Purity Chemical Structure
T3158L Harman hydrochloride
哈尔满盐酸盐
21655-84-5 99.95%
Harman hydrochloride 可以以 AhR 依赖性方式直接诱导 CYP1A1 基因表达,可能代表了harman 促进致突变性、共致突变性和致癌性的新机制。
T3811 Ginsenoside C-K
人参皂苷 C-K
39262-14-1 98.09%
Ginsenoside C-K (Ginsenoside K) 是 Ginsenoside Rb1 的细菌代谢物,可通过抑制诱生型一氧化氮合酶和COX-2来发挥抗炎作用。它在人肝微粒体中抑制CYP2C9和CYP2A6活性,IC50分别为 32.0±3.6 和 63.6±4.2 μM。
TN2144 Resveratroloside
白藜芦醇-4'-O-葡萄糖苷
38963-95-0
Resveratroloside 是α-glucosidase 的竞争性抑制剂,可以对血糖水平进行调节,对心脏具有保护作用。
T8182 Guanfu base A
关附甲素
1394-48-5 98%
Guanfu base A 是一种生物碱,分离自 Aconitum coreanum,是非竞争性 CYP2D6抑制剂,对人肝微粒体 (HLM) 的 Ki 为 1.20 μM,对人重组体 (rCYP2D6) 的 Ki 为 0.37 μM。它也是 CYP2D 的有效竞争抑制剂。它还能抑制 HERG 通道电流。Guan-fu ...
TN4800 Pisatin
化合物 TN4800
20186-22-5 98%
Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
TN3294 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
化合物 TN3294
67667-71-4 98%
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TQ0109 Cephaeline dihydrochloride
盐酸吐根酚碱
5853-29-2 98%
(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
T10535 BI 653048
化合物 T10535
1198784-72-3 98%
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
TN4424 Lecanoric acid
化合物 TN4424
480-56-8 98%
Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
TN4277 Isocupressic acid
化合物 TN4277
1909-91-7 98%
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
TMA2106 (-)-Sparteine
化合物 TMA2106
24915-04-6 98%
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 ...
TN5278 Zederone
化合物 TN5278
7727-79-9 98%
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN3300 8alpha-Tigloyloxyhirsutinolide 13-O-acetate
化合物 TN3300
83182-58-5 98%
8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
TMA0164 15-Hydroxydehydroabietic acid
化合物 TMA0164
54113-95-0 98%
15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
TN2147 Retrorsine
倒千里光碱
480-54-6 98%
Retrorsine 特异性地抑制肝细胞增殖,并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。
T10891 CRTH2-IN-1
化合物 T10891
926661-54-3 98%
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
TN1378 α-Viniferin
α-葡萄素
62218-13-7 98%
α-Viniferin 属于一类有机化合物,也称为2-芳基苯并呋喃类黄酮,是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性
TN3080 5,6,7-Trimethoxycoumarin
化合物 TN3080
55085-47-7 98%
5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp l...
T6051 Orteronel
化合物(S)-Orteronel
566939-85-3 98%
(S)-Orteronel ((S)-Orteronel) 是人17,20-裂解酶 (17,20-lyase, CYP17) 选择性抑制剂(IC50:38 nM),CYP17对(S)-Orteronel 选择性比对 11-hydroxylase 及 CYP3A4 高 1000 多倍。
T11964 MCH-1 antagonist 1
化合物 T11964
1039825-68-7 98%
MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist (Ki: 2.6 nM).
Harman hydrochloride
T3158L
Harman hydrochloride 可以以 AhR 依赖性方式直接诱导 CYP1A1 基因表达,可能代表了harman 促进致突变性、共致突变性和致癌性的新机制。
Ginsenoside C-K
T3811
Ginsenoside C-K (Ginsenoside K) 是 Ginsenoside Rb1 的细菌代谢物,可通过抑制诱生型一氧化氮合酶和COX-2来发挥抗炎作用。它在人肝微粒体中抑制CYP2C9和CYP2A6活性,IC50分别为 32.0±3.6 和 63.6±4.2 μM。
Resveratroloside
TN2144
Resveratroloside 是α-glucosidase 的竞争性抑制剂,可以对血糖水平进行调节,对心脏具有保护作用。
Guanfu base A
T8182
Guanfu base A 是一种生物碱,分离自 Aconitum coreanum,是非竞争性 CYP2D6抑制剂,对人肝微粒体 (HLM) 的 Ki 为 1.20 μM,对人重组体 (rCYP2D6) 的 Ki 为 0.37 μM。它也是 CYP2D 的有效竞争抑制剂。它还能抑制 HERG 通道电流。Guan-fu ...
Pisatin
TN4800
Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
TN3294
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
Cephaeline dihydrochloride
TQ0109
(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
BI 653048
T10535
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
Lecanoric acid
TN4424
Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
Isocupressic acid
TN4277
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
(-)-Sparteine
TMA2106
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 ...
Zederone
TN5278
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
8alpha-Tigloyloxyhirsutinolide 13-O-acetate
TN3300
8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
15-Hydroxydehydroabietic acid
TMA0164
15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
Retrorsine
TN2147
Retrorsine 特异性地抑制肝细胞增殖,并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。
CRTH2-IN-1
T10891
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
α-Viniferin
TN1378
α-Viniferin 属于一类有机化合物,也称为2-芳基苯并呋喃类黄酮,是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性
5,6,7-Trimethoxycoumarin
TN3080
5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp l...
Orteronel
T6051
(S)-Orteronel ((S)-Orteronel) 是人17,20-裂解酶 (17,20-lyase, CYP17) 选择性抑制剂(IC50:38 nM),CYP17对(S)-Orteronel 选择性比对 11-hydroxylase 及 CYP3A4 高 1000 多倍。
MCH-1 antagonist 1
T11964
MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist (Ki: 2.6 nM).
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