MTP

Dirlotapide (CP742033) 属于MTP抑制剂，是一种肠道选择性微粒体甘油三酯转移蛋白抑制剂，通过增加肽YY释放减少食物摄入，用于减轻糖尿病狗体重。

Lomitapide (AEGR-733) 是一种高效的微粒体甘油三酯转移蛋白(MTP)抑制剂，体内试验的IC50值为8 nM。

Lomitapide Mesylate (BMS-201038 mesylate) 是一种高效MTP 蛋白抑制剂，其体外IC50值为8 nM。

Granotapide 是一种微粒体甘油三酯转移蛋白（MTP）抑制剂，治疗和而预防动脉硬化，冠状动脉疾病，代谢综合征，肥胖，糖尿病，糖尿病前期和高血压。

KD-026 (SLx 4090) 是具有口服活性的、肠细胞特异性的微粒体甘油三酯转移蛋白 (MTP)抑制剂，IC50为 8.0 nM。KD-026 (SLx 4090) 在糖尿病2型中有研究的价值。

LAB687 (Compound 2a) 是一类微粒体甘油三酯转运蛋白 (MTP) 的强效抑制剂，其在 HepG2 细胞中抑制载脂蛋白 B (apoB) 分泌的IC50为 0.9 nM。同时，LAB687 作为Smoothened (Smo)的拮抗剂，在小鼠和人类中对Smo受体的IC50分别为 2.48 和 3.42 μM。此化合物能够有效降低甘油三酯和低密度脂蛋白胆固醇 (LDL-C) 的水平，并阻断Hedgehog信号通路。

CP-346086 is a highly potent and orally bioavailable inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM against both human and rodent MTP. This compound effectively reduces plasma levels of cholesterol and triglycerides when administered in vivo.

PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).

CP-346086 dihydrate is a potent and orally active inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM for both human and rodent MTP. This compound effectively lowers plasma cholesterol and triglyceride levels in vivo.

Implitapide Racemate is the racemate of Implitapide. Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

CP-319340 free base is a inhibitor of microsomal triglyceride transfer protein (MTP) .

Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).