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Epigenetic Reader Domain

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T31221L DBRD9 HCl
化合物dBRD9盐酸盐
2341840-98-8 98%
dBRD9 HCl 是一种PROTAC,包含cereblon E3连接酶配体与BRD9抑制剂BI 7273。dBRD9 HCl 是有效和选择性的BRD9降解剂,在MOLM-13细胞中IC50的为56.6nM。dBRD9 HCl 在浓度高达5μM 时不会降解BRD4或BRD7。dBRD9 HCl 在人AML 细胞系中显示出...
T15014 CTPB
化合物 T15014
586976-24-1 98%
CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
T17249 VZ185
化合物 T17249
2306193-61-1 98%
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
T11292 FKBP12 PROTAC dTAG-7
化合物 T11292
2064175-32-0 98%
FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin l...
T15419 GS-626510
化合物 T15419
1637770-13-8 98%
GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
T10520 BET-IN-2
化合物 T10520
2104688-91-5 98%
BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
T13849 PROTAC BET Degrader-1
化合物 T13849
2093386-22-0 98%
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
T14512 BAZ2-ICR
化合物 T14512
1665195-94-7 98%
BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM an...
T11597 IACS-9571
化合物 T11597
1800477-30-8 98%
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
T15443 GSK8814
化合物 T15443
1997369-78-4 98%
GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan). GSK8814 displays 500-fold sel...
T15397 GNE-049
化合物 T15397
1936421-41-8 98%
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, resp...
T17294 ZL0454
化合物 T17294
2229042-77-5 98%
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
T13835 PROTAC BRD4 Degrader-3
化合物 T13835
2313234-00-1 98%
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
T13785 MZP-54
化合物 T13785
2010159-47-2 98%
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
T12560 PROTAC BRD9 Degrader-1
化合物 T12560
2097971-01-0 98%
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
T11291 FKBP12 PROTAC dTAG-13
化合物 T11291
2064175-41-1 98%
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) al...
T13850 PROTAC BET degrader-3
化合物 T13850
T13850 98%
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
T15399 GNE-207
化合物 T15399
2158266-58-9 98%
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207...
T17297 ZXH-3-26
化合物 T17297
2243076-67-5 98%
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
T13977 (R)-UT-155
化合物 T13977
2031161-54-1 98%
(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
dBRD9 HCl
T31221L
dBRD9 HCl 是一种PROTAC,包含cereblon E3连接酶配体与BRD9抑制剂BI 7273。dBRD9 HCl 是有效和选择性的BRD9降解剂,在MOLM-13细胞中IC50的为56.6nM。dBRD9 HCl 在浓度高达5μM 时不会降解BRD4或BRD7。dBRD9 HCl 在人AML 细胞系中显示出...
CTPB
T15014
CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
VZ185
T17249
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
FKBP12 PROTAC dTAG-7
T11292
FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin l...
GS-626510
T15419
GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
BET-IN-2
T10520
BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
PROTAC BET Degrader-1
T13849
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
BAZ2-ICR
T14512
BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM an...
IACS-9571
T11597
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
GSK8814
T15443
GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan). GSK8814 displays 500-fold sel...
GNE-049
T15397
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, resp...
ZL0454
T17294
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
PROTAC BRD4 Degrader-3
T13835
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
MZP-54
T13785
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
PROTAC BRD9 Degrader-1
T12560
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
FKBP12 PROTAC dTAG-13
T11291
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) al...
PROTAC BET degrader-3
T13850
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
GNE-207
T15399
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207...
ZXH-3-26
T17297
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
(R)-UT-155
T13977
(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
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