规格

价格

库存

数量

1 mg

¥ 4,800

5日内发货

5 mg

¥ 10,600

5日内发货

10 mg

¥ 15,800

5日内发货

1 mL x 10 mM (in DMSO)

¥ 19,100

5日内发货

生物活性

产品描述	AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research. AR/BRD4 RIPTAC-1 is additionally applicable in molecular oncology research for investigating androgen receptor–epigenetic regulator interactions and for studying proximity-induced protein complex formation mechanisms in tumor-associated transcriptional regulation systems.
靶点活性	T47D cells:＜0.5 μM (GI50)
体外活性	方法：体外培养 T47D 细胞，经 AR/BRD4 RIPTAC-1 (Antiproliferative agent-71) 作用 72h，测定细胞增殖半数抑制浓度 GI₅₀。结果：AR/BRD4 RIPTAC-1 (Antiproliferative agent-71)可抑制 T47D 细胞生长，GI₅₀低于 0.5 μM [1]。
体内活性	方法：对荷 VCaP 肿瘤的 CB17.SCID 小鼠口服给药，连续处理 7 天，观察肿瘤生长状态。结果：AR/BRD4 RIPTAC-1 (Antiproliferative agent-71) 可有效抑制小鼠体内肿瘤增殖 [1]。
别名	Antiproliferative agent-71

化学信息

分子量	907.09
分子式	C₅₀H₅₄N₁₀O₅S
CAS No.	3083307-42-7
Smiles	O(C1CC2(C1)CCN(CC2)C=3N=CC(C(N[C@H]4C(C)(C)[C@H](OC5=CC(OC)=C(C#N)C=C5)C4(C)C)=O)=CN3)C6=CC=C(C=C6)C=7C8=C(N9C([C@H](CC%10=NC=CO%10)N7)=NN=C9C)SC(C)=C8C

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 40 mg/mL (44.1 mM), Sonication is recommended.

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

AR/BRD4 RIPTAC-1