synthase

FIN56 是一种铁死亡特异性诱导剂，能结合并激活角鲨烯合酶，可通过诱导 GPX4 降解来诱导铁死亡。

PF-04802367是 GSK-3高选择性抑制剂，对 GSK-3β酶的 IC50为 2.1 nM。它抑制两种 GSK-3 亚型（GSK-3α和GSK-3β）效果差不多，IC50值分别为 10.0 和 9.0 nM。它具有理想的中枢神经系统特性和效力。

ATP synthase inhibitor 1 是 F1/FO-ATP 合酶复合物 c 亚基的有效抑制剂，抑制线粒体通透性转换孔的开放。

ATP synthase inhibitor3（compound PT6）作为一种分枝杆菌F-ATP合酶抑制剂（IC50=0.788 μM），显示出口服活性。此化合物能有效抑制体外Mycobacterium tuberculosis H37Rv菌株（ATCC-27294）的生长，并在IC50值达30 μM时显著降低细胞内ATP水平。

Squalene synthase-IN-2 (compound isomer A-(1S, 3R)-14i) 是一种可口服的角鲨烯合酶 (squalene synthase) 抑制剂，其对角鲨烯合酶 (squalene synthase) 和胆固醇合成酶 (cholesterol synthesis) 的IC50值分别为3.4 nM和99 nM。该化合物能够降低血浆胆固醇和甘油三酯。

S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively[1]. [1]. Arindam Talukdar, et al. Discovery and Development of a Small Molecule Library With Lumazine Synthase Inhibitory Activity. J Org Chem. 2009 Aug 7;74(15):5123-34.

Polyketide synthase 13-IN-3 (compound 41) is a potent inhibitor of polyketide synthase 13, demonstrating a minimum inhibitory concentration (MIC) range of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.

Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor.

Phospho-Glycogen Synthase Peptide-2, a substrate for glycogen synthase kinase-3 (GSK-3), serves as a peptide substrate effective in the affinity purification of protein-serine kinases.

Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) 是一种可逆的醋酸盐依赖性乙酰辅酶 A 合成酶 2 抑制剂，IC50为 0.6 µM，可抑制呼吸道合胞病毒。

Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 value of 0.09 mM and a K i value of 0.12 mM. This compound exhibits antimicrobial activities in vitro and demonstrates synergistic or additive effects when combined with fluconazole or polyoxin B [1].

Chitin synthase inhibitor 3 (compound 2d) 是一种高效的chitin synthase抑制剂，具有0.16 mM的IC50值，并对candida albicans显示出1 μg/mL的MIC，表现出抗真菌活性。

Polyketide synthase 13-IN-2 (comp 42) is a potent inhibitor of polyketide synthase 13 in Mycobacterium tuberculosis. It demonstrates a minimum inhibitory concentration (MIC) of 0.25 μg/mL [1].

Glucosylceramide synthase-IN-3 (compound BZ1) is a highly potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 value of 16 nM for human GCS. This compound, designated as Glucosylceramide synthase-IN-3, finds potential applications in Gaucher's disease research [1] [2].

ATP synthase inhibitor2 是一个铜绿假单胞菌 (PA)ATP synthase 抑制剂 (IC50=10 μg/mL)，在 128 μg/mL 时可完全抑制铜绿假单胞菌 (PA) 的 ATP 合成活性。

GlcN-6-P Synthase-IN-1 (Compound 4d) is a potent inhibitor of Glucosamine-6-phosphate (GlcN-6-P) synthase, with an IC50 of 3.47 μM. This compound demonstrates remarkable antimicrobial activity and exhibits excellent penetration in the central nervous system. Additionally, GlcN-6-P Synthase-IN-1 is capable of inhibiting cytochrome P450, specifically the CYP3A4 isoform [1].

Chitin synthase inhibitor 1 是有效的、选择性的几丁质合酶 (CHS) 抑制剂，IC50值为0.12 mM。Chitin synthase inhibitor 1 强效抑制耐药真菌变体。

Chitin synthase inhibitor 8 是一种 chitin synthase (CHS) 抑制剂，具有广谱抗真菌作用，能够用于真菌感染相关研究。

Chitin synthase inhibitor 7 (compound 9c) 是一种 chitin synthase (CHS) 的有效抑制剂 (IC50: 0.37 nM)。Chitin synthase inhibitor 7 对耐药真菌具有广谱抗真菌作用。Chitin synthase inhibitor 7 能够用于研究真菌感染。

Glucosylceramide synthase-IN-2 (compound T-690) 是一种有效的、具有血脑屏障通透性的、口服具有活力的 glucosylceramide synthase (GCS) 抑制剂，作用于人 GCS (IC50: 15 nM) 和小鼠 GCS (IC50: 190 nM)。Glucosylceramide synthase-IN-2 能够非竞争性抑制 C8 神经酰胺和 UDP 葡萄糖。Glucosylceramide synthase-IN-2 能够用于研究戈谢病。

Dihydropteroate synthase-IN-1 (compound 5g) 是一种dihydropteroate synthase (DHPS) 的有效抑制剂，对细胞色素 P450 具有抑制作用。Dihydropteroate synthase-IN-1 具有抗微生物活性和抗真菌作用。Dihydropteroate synthase-IN-1 能够用作放射诊断影像材料。

Chitin synthase inhibitor 6 (compound 9b) 是一种 chitin synthase (CHS) 的有效抑制剂 (IC50: 0.21 mM)。Chitin synthase inhibitor 6 对耐药真菌表现出广谱抗真菌效果，能够用于研究真菌感染。

Chitin synthase inhibitor 9 是一种几丁质合成酶 (chitin synthase, CHS) 抑制剂，表现出广谱抗真菌效果。Chitin synthase inhibitor 9 能够用于进行真菌感染相关研究。

Glucosylceramide synthase-IN-1 (T-036) 是一种有效的、口服具有活力的、具有血脑屏障通透性的 glucosylceramide synthase (GCS) 抑制剂，作用于人 GCS (IC50: 31 nM) 和小鼠 GCS (IC50: 51 nM)。Glucosylceramide synthase-IN-1 能够用于研究戈谢病。