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药物功能重定位化合物库

药物功能重定位化合物库

产品编号 L9200 Drug Repurposing Compound Library
  库化合物信息   Excel SDF

传统的药物开发涉及从头确认和验证新分子实体,这是一个耗时且成本高昂的过程,随着对药物安全性及有效性的要求不断提高,开发新药的成本还将持续上涨。由于时间和成本大幅降低,近年来药物功能重定位受到越来越多关注,高内涵筛选、新的生物标志物发现和生物信息学的快速发展为基于靶点或细胞的药物重定位创造了机会。

TargetMol 药物功能重定位化合物库收集了4330 种已上市和进入临床期的药物,这些化合物经过大量的临床前研究实验,具有活性高、毒性低和机制明确的特点,适用于药物筛选的同时,也是细胞诱导分化的有力工具。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
我们的产品含有多种规格,如需了解具体的规格以及价格信息,请联系我们咨询订购,对于大额的订购,我们还有额外的优惠!
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如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
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产品描述

  • 4330种全球上市药物和临床药物的独特集合,可用于高通量筛选和高内涵筛选,是老药新用、新的药物靶点筛选和细胞诱导的有效工具。
  • 是整个行业规模领先的药物功能重定位化合物库;
  • 所有上市化合物得到FDA、EMA、NMPA等权威部门审批或收录在USP、EP、BP、JP、CP等药典文献中;
  • 涵盖多个研究领域:肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等;
  • 靶点多样,包括5-HT Receptor、Sodium Channel、p38 MAPK、PI3K、MEK等;
  • 详细的说明书,化合物结构、靶点信息、适应症信息、活性描述等;
  • 结构多样,药效显著,可渗透细胞;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L9200)
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化合物库组成

Autophagy (449)
Antibacterial (435)
Apoptosis (421)
Antibiotic (393)
Endogenous Metabolite (318)
5-HT Receptor (193)
Adrenergic Receptor (179)
AChR (153)
COX (136)
Dopamine Receptor (125)
Histamine Receptor (119)
DNA/RNA Synthesis (117)
Parasite (112)
HIV Protease (109)
Antifungal (96)
Sodium Channel (94)
Calcium Channel (86)
Potassium Channel (84)
VEGFR (78)
Topoisomerase (73)
EGFR (71)
PI3K (64)
PDE (62)
Reactive Oxygen Species (62)
P450 (58)
FLT (56)
Influenza Virus (56)
Ferroptosis (56)
GABA Receptor (54)
Estrogen/progestogen Receptor (53)
NF-κB (53)
PPAR (52)
CDK (52)
Dehydrogenase (51)
Glucocorticoid Receptor (51)
SARS-CoV (50)
HCV Protease (48)
PDGFR (48)
JAK (48)
c-Kit (46)
Microtubule Associated (46)
HDAC (45)
FGFR (43)
Prostaglandin Receptor (42)
RAAS (41)
c-Met/HGFR (40)
mTOR (39)
Mitophagy (39)
Nucleoside Antimetabolite/Analog (35)
Src (34)
Reverse Transcriptase (33)
Estrogen Receptor/ERR (32)
Serotonin Transporter (32)
HBV (32)
Virus Protease (30)
iGluR (30)
HSV (30)
Adenosine Receptor (30)
ribosome (29)
Androgen Receptor (29)
Bcr-Abl (29)
Proteasome (29)
Tyrosine Kinases (28)
Opioid Receptor (28)
AChE (27)
TNF (27)
Norepinephrine (26)
Raf (26)
MAO (25)
ATPase (25)
Progesterone Receptor (25)
GPR (25)
ROS (23)
GluR (23)
Akt (23)
NMDAR (23)
Phosphatase (23)
Proton pump (22)
Carbonic Anhydrase (22)
DNA Alkylator/Crosslinker (22)
HIF/HIF Prolyl-Hydroxylase (22)
Transferase (22)
HER (22)
Aurora Kinase (21)
PARP (21)
Epigenetic Reader Domain (21)
Beta Amyloid (21)
P-gp (21)
Antifection (21)
PKC (21)
BTK (21)
HSP (20)
MEK (20)
TRP/TRPV Channel (20)
p38 MAPK (20)
Monoamine Oxidase (19)
IL Receptor (19)
Thrombin (18)
DPP-4 (18)
ERK (18)
Antioxidant (18)
c-RET (18)
Mitochondrial Metabolism (18)
Interleukin (17)
Drug Metabolite (17)
Trk receptor (17)
Phospholipase (17)
ALK (17)
MMP (17)
AMPK (17)
CXCR (17)
BCL (16)
Retinoid Receptor (16)
E1/E2/E3 Enzyme (15)
DNA Alkylation (15)
Endothelin Receptor (15)
Thyroid hormone receptor(THR) (15)
GSK-3 (15)
c-Fms (15)
NO Synthase (15)
Caspase (15)
Antiviral (15)
Histone Methyltransferase (15)
Gamma-secretase (14)
TLR (14)
Antifolate (14)
Lipoxygenase (14)
STAT (14)
TAM Receptor (14)
MRP (14)
SGLT (13)
Syk (12)
HIF (12)
PKA (12)
CCR (12)
Chk (12)
CFTR (12)
DNA-PK (12)
HMG-CoA Reductase (12)
NADPH (12)
p53 (12)
Neurokinin receptor (11)
LPL Receptor (11)
DHFR (11)
GNRH Receptor (11)
S1P Receptor (11)
IGF-1R (11)
FAK (11)
Nrf2 (11)
Guanylate cyclase (11)
Amino Acids and Derivatives (11)
TGF-beta/Smad (10)
CaMK (10)
FXR (10)
Chloride channel (10)
ROCK (10)
Serine Protease (10)
CSF-1R (10)
DNA Methyltransferase (10)
Integrin (10)
Factor Xa (10)
Wnt/beta-catenin (10)
DNA gyrase (10)
Hedgehog/Smoothened (10)
P2X Receptor (9)
Glucosidase (9)
S6 Kinase (9)
Vasopressin Receptor (9)
Reductase (9)
Mdm2 (9)
Histone Demethylase (9)
P2Y Receptor (9)
Sigma receptor (9)
Cannabinoid Receptor (9)
Hydroxylase (9)
PLK (9)
ABC (8)
Smo (8)
Glutathione Peroxidase (8)
CAT (8)
OX Receptor (8)
IAP (8)
Tyrosinase (8)
JNK (8)
Indoleamine 2,3-Dioxygenase (IDO) (8)
CETP (8)
Leukotriene Receptor (8)
RSV (7)
Fatty Acid Synthase (7)
Aryl Hydrocarbon Receptor (7)
Ligand for E3 Ligase (7)
LTR (7)
BACE (7)
Xanthine Oxidase (7)
ROS Kinase (7)
ATM/ATR (7)
Beta-Secretase (7)
Glucagon Receptor (7)
Sirtuin (7)
Ras (7)
Monoamine Transporter (6)
PAK (6)
Aminopeptidase (6)
Complement System (6)
ROR (6)
AhR (6)
IκB/IKK (6)
Kinesin (6)
Cysteine Protease (6)
RIP kinase (6)
DNA (6)
Isocitrate Dehydrogenase (IDH) (6)
Casein Kinase (6)
FAAH (5)
Imidazoline Receptor (5)
Glucokinase (5)
Cell wall (5)
Tie-2 (5)
NOD (5)
Anti-infection (5)
Liver X Receptor (5)
IDO (5)
Acyltransferase (5)
GPCR19 (5)
PGE Synthase (5)
Ephrin Receptor (5)
Pim (5)
NOS (5)
IFNAR (5)
cholecystokinin (4)
CaSR (4)
Gap Junction Protein (4)
Melatonin Receptor (4)
CGRP Receptor (4)
Serine/threonin kinase (4)
CRFR (4)
MT Receptor (4)
Bradykinin Receptor (4)
GHSR (4)
KSP (4)
NOD-like Receptor (NLR) (4)
Acetyl-CoA Carboxylase (4)
Lipid (4)
Molecular Glues (4)
Neprilysin (4)
UGT (4)
DprE1 (4)
Decarboxylase (4)
Melanocortin Receptor (4)
GlyT (4)
Rho (3)
Aromatase (3)
Adenosine deaminase (3)
NAMPT (3)
Free radical scavengers (3)
Protease-activated Receptor (3)
Hexokinase (3)
Arginase (3)
CRM1 (3)
Monocarboxylate transporter (3)
Annexin A (3)
NADPH-oxidase (3)
IRAK (3)
Telomerase (3)
STING (3)
Oxytocin Receptor (3)
PDK (3)
LDL (3)
Neuropeptide Y Receptor (3)
OAT (3)
LPA Receptor (3)
Myosin (3)
Na-K-Cl cotransporter (3)
GST (3)
Somatostatin (3)
PD-1/PD-L1 (2)
Wee1 (2)
Taste receptor (2)
PYK2 (2)
MLK (2)
Glutathione reductase (2)
advanced glycation end products (2)
IRE1 (2)
Integrase (2)
NEDD8 (2)
DUB (2)
Porcupine (2)
PAI-1 (2)
Ligands for Target Protein for PROTAC (2)
VDA (2)
CD73 (2)
Phosphorylase (2)
PKM (2)
TOPK (2)
Thrombopoietin Receptor (2)
BCRP (2)
Discoidin Domain Receptor (DDR) (2)
YAP (2)
Aquaporin (2)
Epoxide Hydrolase (2)
Lipase (2)
ATP Citrate Lyase (2)
Histone Acetyltransferase (2)
Galectin (2)
MAPK (2)
PROTAC Linker (2)
MTH1 (1)
FLAP (1)
Methionine Adenosyltransferase (MAT) (1)
RAR/RXR  (1)
GTPase (1)
c-Myc (1)
Thioredoxin (1)
Motilin Receptor (1)
Na+/Ca2+ Exchanger (1)
Adiponectin receptor (1)
MALT (1)
p97 (1)
PI4K (1)
NPC1L1 (1)
DYRK (1)
LHRH (1)
KLF (1)
Fas/FasL (1)
CRISPR/Cas9 (1)
PROTACs (1)
PERK (1)
Dynamin (1)
Glutaminase (1)
OXPHOS (1)
Hydrogenase (1)
Hippo pathway (1)
SGK (1)
MNK (1)
BMI-1 (1)
N-Acetylglucosaminyltransferase (1)
AAK1 (AP2 associated kinase 1) (1)
MELK (1)
Hck (1)
PAD (1)
GRK (1)
PAFR (1)
Stearoyl-CoA Desaturase (SCD) (1)
Pyroptosis (1)
Survivin (1)
cAMP (1)
Platelet aggregation (1)
Immunology/Inflammation related (1)
VDAC (1)
Angiotensin-converting Enzyme (ACE) (1)
GSNOR (1)
GluCls (1)
Anion Exchanger (1)
Adenylyl cyclase (1)
ACK (1)
transporter (1)
Stemness kinase (1)
ASK (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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