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Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984)
还可以产品编号 TMAH-00900
别名 Serine/threonine protein kinase GSK3A, Phospho-GSK3A/GSK3B (Y216, 279), GSK3alpha, Gsk3a, GSK-3 alpha, GSK 3A, GSK 3 alpha, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase 3 alpha, DKFZp686D0638
Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984) 是一种抗体，靶向 Phospho-GSK3A/GSK3B (Tyr216, 279)。Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984) 可用于 ELISA, IHC。
Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984)
Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984)
还可以产品编号 TMAH-00900 别名 Serine/threonine protein kinase GSK3A, Phospho-GSK3A/GSK3B (Y216, 279), GSK3alpha, Gsk3a, GSK-3 alpha, GSK 3A, GSK 3 alpha, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase 3 alpha, DKFZp686D0638
Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984) 是一种抗体，靶向 Phospho-GSK3A/GSK3B (Tyr216, 279)。Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984) is an antibody targeting Phospho-GSK3A/GSK3B (Tyr216, 279). Anti-Phospho-GSK3A/GSK3B (Tyr216, 279) Antibody (5B984) can be used in ELISA, IHC. |
| 别名 | Serine/threonine protein kinase GSK3A, Phospho-GSK3A/GSK3B (Y216, 279), GSK3alpha, Gsk3a, GSK-3 alpha, GSK 3A, GSK 3 alpha, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase 3 alpha, DKFZp686D0638 |
| Ig Type | Rabbit IgG |
| 克隆号 | 5B984 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00900 diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-GSK3A/GSK3B (Y216 + Y279) |
| 抗原种属 | Human |
| 基因ID | 2931 |
| Uniprot ID | |
| 研究领域 | Neuroscience |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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