Anti-ALOX12 Polyclonal Antibody is a Rabbit antibody targeting ALOX12. Anti-ALOX12 Polyclonal Antibody can be used in WB.

IgG

Human,Mouse (predicted:Rat)

Sample:
Lane 1: Esophagus (Mouse) Lysate at 40 μg
Lane 2: A431 (Human) Cell Lysate at 30 μg
Lane 3: Hela (Human) Cell Lysate at 30 μg
Lane 4: A549 (Human) Cell Lysate at 30 μg
Lane 5: 293T (Human) Cell Lysate at 30 μg
Lane 6: U937 (Human) Cell Lysate at 30 μg
Lane 7: K562 (Human) Cell Lysate at 30 μg
Primary: Anti-ALOX12 (TMAB-00097) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 76 kDa
Observed band size: 76 kDa

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human 12 Lipoxygenase

Human

ALOX12B

Arachidonate 12-lipoxygenase, 12R-type

Lipid metabolism,Lipases,Cell differentiation,Lipases

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750,