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Aromatase/CYP19A1 Protein, Human, Recombinant (His)

Aromatase/CYP19A1 Protein, Human, Recombinant (His)

产品编号 TMPH-00956
别名: ARO1, CYP19A1, Estrogen synthase, Cytochrome P450 19A1, Aromatase, CYPXIX, CYAR, Cytochrome P-450AROM, CYP19

Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli.

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Aromatase/CYP19A1 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
20 μg ¥ 1,800 20日内发货
100 μg ¥ 3,420 20日内发货
1 mg ¥ 14,600 20日内发货
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产品目录号及名称: Aromatase/CYP19A1 Protein, Human, Recombinant (His) (TMPH-00956)
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生物活性
技术参数
产品性质
产品描述 Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli.
种属 Human
表达系统 E. coli
标签 N-6xHis
蛋白编号 P11511
别名 ARO1, CYP19A1, Estrogen synthase, Cytochrome P450 19A1, Aromatase, CYPXIX, CYAR, Cytochrome P-450AROM, CYP19
氨基酸序列 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
蛋白构建 1-503 aa
蛋白纯度 > 85% as determined by SDS-PAGE.
分子量 62.0 kDa (predicted)
缓冲液 If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

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Keywords

Aromatase/CYP19A1 Protein, Human, Recombinant (His) ARO1 CYP19A1 Estrogen synthase Cytochrome P450 19A1 Aromatase CYPXIX CYAR Cytochrome P-450AROM CYP19 recombinant recombinant-proteins proteins protein

 

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