Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZZL-7是一种起效快的抗抑郁药。ZZL-7破坏中缝背核(DRN)神经元一氧化氮合酶(nNOS)和血清素转运蛋白(SERT)之间的相互作用。ZZL-7可以很容易地穿过血脑屏障。ZZL-7在重度抑郁症(MDD)中具有研究价值。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 215 | 现货 | ||
5 mg | ¥ 472 | 现货 | ||
10 mg | ¥ 747 | 现货 | ||
25 mg | ¥ 1,660 | 现货 | ||
50 mg | ¥ 2,490 | 现货 | ||
100 mg | ¥ 3,730 | 现货 | ||
200 mg | ¥ 5,190 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 483 | 现货 |
产品描述 | ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the blood-brain barrier readily. ZZL-7 has research value in major depressive disorder (MDD). |
体外活性 | In 293T cells transfected with nNOS and SERT, ZZL-7 (1.0 μM; 2 h) significantly decreases the SERT-nNOS complex level[1]. |
体内活性 | ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment. ZZL-7 (10, 20, and 40 mg/kg; Intragastric administration; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment. ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time[1]. |
分子量 | 244.29 |
分子式 | C11H20N2O4 |
CAS No. | 99141-91-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (49.12 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.0935 mL | 20.4675 mL | 40.935 mL | 102.3374 mL |
5 mM | 0.8187 mL | 4.0935 mL | 8.187 mL | 20.4675 mL | |
10 mM | 0.4093 mL | 2.0467 mL | 4.0935 mL | 10.2337 mL | |
20 mM | 0.2047 mL | 1.0234 mL | 2.0467 mL | 5.1169 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ZZL-7 99141-91-0 Neuroscience Serotonin Transporter ZZL 7 ZZL7 Inhibitor inhibitor inhibit