56
10
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71534L |
CIA-1 (Free base)
CIA-1(Free base) |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
CIA-1 (Free base) 是一种核受体 COUP-TFII 抑制剂,在前列腺癌细胞系中IC50 值在 1.2 μM 到 7.6 μM 之间。CIA-1 (Free base) 在前列腺癌异种移植小鼠模型中抑制肿瘤生长。 | |||
T71534 |
CIA-1 hcl(452087-38-6 Free base)
|
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
CIA-1对核受体COUP-TFII 具有抑制作用,在前列腺癌细胞系中IC50范围从1.2μM 到7.6μM 之间。CIA-1在体外抑制多种前列腺癌细胞系的生长并抑制COUP-TFII 活性以调节其靶基因。CIA-1在体内对前列腺癌异种移植小鼠模型中的肿瘤生长具有抑制作用。 | |||
T2057 |
BVT 2733
|
Dehydrogenase | Metabolism |
BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病具有潜在的研究价值。 | |||
T4195 |
Betahistine
PT 9 base,倍他司汀,Vasomotal,Serc base |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂,可用作血管扩张剂,用于类风湿性关节炎的研究。 | |||
T0246 |
Betahistine dihydrochloride
PT-9,Betahistine 2HCl,盐酸倍他司汀 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Betahistine dihydrochloride (Betahistine 2HCl) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂,可用作血管扩张剂,用于类风湿性关节炎的研究。 | |||
T72006 |
DCAI Hydrochloride
|
||
DCAI hydrochloride is an inhibitor of nucleotide exchange and nucleotide release, by binding to the pocket adjacent to the Ras-SOS interface. | |||
T2125 |
Trametinib
GSK1120212,曲美替尼,JTP-74057 |
Apoptosis; MEK; Autophagy | Apoptosis; Autophagy; MAPK |
Trametinib (GSK1120212) 是一种 MEK 抑制剂,抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM),具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬,诱导凋亡。 | |||
T5857 |
Trametinib (DMSO solvate)
Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate) |
Apoptosis; MEK | Apoptosis; MAPK |
Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) 是一种口服有效的 MEK 抑制剂,抑制 MEK1 和 MEK2 的 IC50分别为 2 nM。它还能激活自噬,诱导凋亡。 | |||
T21649L |
GnRH Associated Peptide (GAP) (1-13), human Acetate
GnRH Associated Peptide (GAP) (1-13), human Acetate (100111-07-7 Free base) |
Others | Others |
GnRH Associated Peptide (GAP) (1-13), human Acetate 被发现是催乳素分泌的有效抑制剂并刺激促性腺激素的释放。用对应于 GAP 序列的肽进行主动免疫导致催乳素分泌大大增加。 | |||
T68043 |
Ciamexon
Ciamexone,BM 41332,BM41332,BM-41332 |
Others | Others |
Ciamexon (Ciamexone) 是一种新型的免疫调节剂,在自身免疫性疾病的实验模型中具有良好的效果,几乎没有显示出细胞毒性。Ciamexon 可用于研究内分泌眼病和糖尿病,在短时间给药后眼科疾病得到轻微改善。 | |||
T17870 |
cIAP1 ligand 1
E3 ligase Ligand 12 |
Others | Others |
cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体,可募集 IAP 泛素连接酶以降解靶蛋白,可用于和雄激素受体配体偶联开发蛋白降解剂,可用于研究前列腺癌。 | |||
T17886 |
cIAP1 Ligand-Linker Conjugates 15 hydrochloride
E3 ligase Ligand-Linker Conjugates 34 hydrochloride |
Others | Others |
cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1]. | |||
T17894 |
cIAP1 Ligand-Linker Conjugates 3
E3 ligase Ligand-Linker Conjugates 40 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1]. | |||
T64302 | XIAP/cIAP1 antagonist-1 | ||
XIAP/cIAP1 antagonist-1 是一种有效的、口服具有活力的 XIAP/cIAP1 拮抗剂,能够作用于 XIAP (EC50: 5.1 nM) 和 cIAP1 (EC50: 0.32 nM)。XIAP/cIAP1 antagonist-1 能够剂量依赖性地抑制体内肿瘤生长。 | |||
T17869 |
cIAP1 ligand 2
E3 ligase Ligand 11 |
Others | Others |
cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER. | |||
T25248 |
Cianopramine
Ro 112465,Ro-112465,Ro112465 |
||
Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals. | |||
T17895 |
cIAP1 Ligand-Linker Conjugates 1
E3 ligase Ligand-Linker Conjugates 41 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 1 is composed of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 1, is particularly useful in the development of SNIPERs[1]. | |||
T39609 |
cIAP1 Ligand-Linker Conjugates 16
cIAP1 Ligand-Linker Conjugates 16 |
||
cIAP1 Ligand-Linker Conjugates 16 refers to a specific type of ligase ligand-linker conjugate, possessing the ability to engage with E3 ligases, which finds application in the synthesis of PROTACs. | |||
T29390 |
m-Ciaamp
3-Carboxyphenyl((N-((4-iodophenyl)acetyl)amino)methyl)phosphonate |
||
3-Carboxyphenyl((N-((4-iodophenyl)acetyl)amino)methyl)phosphonate is a bioactive chemical. | |||
T17884 |
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride
E3 ligase Ligand-Linker Conjugates 33 Hydrochloride |
Others | Others |
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1]. | |||
T17898 |
cIAP1 Ligand-Linker Conjugates 7
E3 ligase Ligand-Linker Conjugates 44 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1]. | |||
T17899 |
cIAP1 Ligand-Linker Conjugates 9
E3 ligase Ligand-Linker Conjugates 45 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1]. | |||
T30929 |
Cianopramine hydrochloride
Cianopramine HCl,Ro 112465 hydrochloride,Ro-11-2465 hydrochloride |
||
Cianopramine hydrochloride is a bio-active chemical. | |||
T39103 |
Pafolacianine
OTL 38 |
||
Pafolacianine (OTL 38) is a near-infrared dye-based fluorescent marker utilized for identifying ovarian cancer lesions during surgeries. | |||
T76324 |
GnRH Associated Peptide (1-24), human
|
||
GnRH Associated Peptide (GAP) (1-24), human 是人类的一个化合物,具体为促性腺激素释放激素相关肽(GAP)的第1至24个氨基酸片段(hGAP-1-24)。该化合物通过3个氨基酸加工位点与黄体生成素释放激素(LH-RH)序列连接。 | |||
T82346 |
Galanin message associated peptide (1-41) amide
|
||
Galanin message-associated peptide (1-41) amide 是肽类激素,结构由41个氨基酸残基组成,并以酰胺形式存在。 | |||
T126403 |
Kaempferol 3-O-vicianoside
|
||
Kaempferol 3-O-vicianoside 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126403,CAS号为 110352-79-9。 | |||
T33889 |
Passitrifasciatin
|
||
Passitrifasciatin is a cyclopentanoid cyanohydrin glycoside isolated from Passiflora trifasciata. | |||
T17885 |
cIAP1 Ligand-Linker Conjugates 11
E3 ligase Ligand-Linker Conjugates 33 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins. | |||
T17889 |
cIAP1 Ligand-Linker Conjugates 14
E3 ligase Ligand-Linker Conjugates 36 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1]. | |||
T79637 | CIAC001 | ||
CIAC001是一种丙酮酸激酶PKM2的抑制剂,它展现出了抗神经炎症活性。这种化合物能够抑制LPS诱导的一氧化氮(NO)产生(IC50=2.5 μM),并保护BV-2免疫活性细胞。在小鼠模型中,CIAC001减轻了慢性吗啡引起的成瘾和神经炎症症状。 | |||
TP1420 |
Microtubule-associated protein tau (26-44)
|
||
Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine. | |||
T17896 |
cIAP1 Ligand-Linker Conjugates 4
E3 ligase Ligand-Linker Conjugates 42 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potential to be utilized in the development of SNIPERs[1]. | |||
T17891 |
cIAP1 Ligand-Linker Conjugates 2
E3 ligase Ligand-Linker Conjugates 37 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1]. | |||
T17888 |
cIAP1 Ligand-Linker Conjugates 6 hydrochloride
E3 ligase Ligand-Linker Conjugates 35 hydrochloride |
Others | Others |
cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1]. | |||
T29841 |
Alcian yellow
C.I. Ingrain Yellow 1 |
||
Alcian yellow is a biomarker. | |||
T29840 |
Alcian blue
|
||
Alcian blue is a copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo. | |||
T76323 |
GnRH Associated Peptide (25-53), human
|
||
GnRH Associated Peptide (GAP) (25-53), human 是来源于人的促性腺激素释放激素相关肽(GAP)的一个特定片段,具体为第25至第53位氨基酸(hGAP-25-53)。本片段可用作免疫原,用以产生含有MC-1、MC-2和MC-3等抗体的抗血清。GAP通过其内含的三个氨基酸加工位点,能与黄体生成素释放激素(LH-RH)序列进行有效连接。 | |||
T40861 |
Nerindocianine
|
||
Nerindocianine is a hydrophilic, fluorescent diagnostic contrast agent that is predominantly metabolized by the kidneys, enabling non-invasive, intraoperative ureteral imaging. | |||
T17897 |
cIAP1 Ligand-Linker Conjugates 13
E3 ligase Ligand-Linker Conjugates 43 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1]. | |||
T17890 |
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride
E3 ligase Ligand-Linker Conjugates 37 Hydrochloride,cIAP1 Ligand-Linker Conjugates 2 Hydrochloride (1312302-14-9 free base) |
Others | Others |
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is utilized in the creation of SNIPERs[1]. | |||
T124331 |
4'-Deoxyprovincialin
|
||
4'-Deoxyprovincialin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124331,CAS号为 72057-04-6。 | |||
T17900 |
cIAP1 Ligand-Linker Conjugates 8
E3 ligase Ligand-Linker Conjugates 46 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1]. | |||
T17892 |
cIAP1 Ligand-Linker Conjugates 12
E3 ligase Ligand-Linker Conjugates 38 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 12 is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 12, is valuable for creating SNIPERs[1]. | |||
T17901 |
cIAP1 Ligand-Linker Conjugates 10
E3 ligase Ligand-Linker Conjugates 47 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10. | |||
T69322 |
cIAP1-IN-D19
|
||
cIAP1-IN-D19 is an inhibitor of E3 ligase activity of cIAP1. | |||
T17887 |
cIAP1 Ligand-Linker Conjugates 15
E3 ligase Ligand-Linker Conjugates 34 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1]. | |||
T17893 |
cIAP1 Ligand-Linker Conjugates 5
E3 ligase Ligand-Linker Conjugates 39 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1]. | |||
T10496 |
Bencianol
ZY15051,苯西阿诺 |
Others | Others |
Bencianol is a semisynthetic flavonoid with anti-spasmogenic activities. | |||
T124855 | Lucialdehyde A | ||
Lucialdehyde A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124855。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S2129 |
Sciadopitysin
|
TNF; NF-κB | Apoptosis; NF-κB |
Sciadopitysin 是一种双黄酮类化合物,来自银杏叶片中。它通过抑制NF-κB 活化并降低c-Fos 和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。 | |||
TN4455 |
Lucialdehyde B
|
Integrase; HSV | Microbiology/Virology |
Lucialdehyde B exhibits potent inhibitory activity against herpes simplex virus. It shows cytotoxic effects on Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines. | |||
TN6102 |
Pistaciamide
|
||
Pistaciamide 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6102,CAS号为 1029004-83-8。 | |||
TN5364 |
Boscialin
|
||
Boscialin can inhibit signal transducer and activator of transcription 1 translocation at a concentration of 10 uM. | |||
TN4195 |
Helicianeoide A
|
Others | Others |
Helicianeoide A 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4195,CAS号为 496066-82-1。 | |||
TN2700 | 2,3-dihydrosciadopitysin | Others | Others |
2,3-dihydrosciadopitysin是一种天然产物,属于罗汉松科罗汉松属,其产品编号为 TN2700,CAS号为 34421-19-7。2,3-dihydrosciadopitysin可用作对照参考。 | |||
T39435 |
Myrciacetin
|
||
Myrciacetin, a flavonoid derived from Rhododendron dauricum, exhibits inhibitory activity against rat lens aldose reductase, as demonstrated by an IC50 value of 13 μM. | |||
TN4196 |
Helicianeoide B
|
Others | Others |
Helicianeoide B 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4196,CAS号为 496066-89-8。 | |||
TN4598 |
Myrciaphenone A
|
Others | Others |
Myrciaphenone A is a natural product from Limoniastrum feei (Girard) Batt. | |||
T3662 |
Eleutheroside E
|
NF-κB | NF-κB |
Eleutheroside E 是刺五加的重要成分,具有抗炎,保护缺血心脏的功能。 |