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Anti-LAMP2 Antibody (1V86)
还可以产品编号 TMAH-00683
别名 lysosomal-associated membrane protein 2, LGP110, LAMPB, LAMP-2, CD107b
Anti-LAMP2 Antibody (1V86) 是一种抗体，靶向 LAMP2。Anti-LAMP2 Antibody (1V86) 可用于 ELISA, IHC。
Anti-LAMP2 Antibody (1V86)
Anti-LAMP2 Antibody (1V86)
还可以产品编号 TMAH-00683 别名 lysosomal-associated membrane protein 2, LGP110, LAMPB, LAMP-2, CD107b
Anti-LAMP2 Antibody (1V86) 是一种抗体，靶向 LAMP2。Anti-LAMP2 Antibody (1V86) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-LAMP2 Antibody (1V86) is an antibody targeting LAMP2. Anti-LAMP2 Antibody (1V86) can be used in ELISA, IHC. |
| 别名 | lysosomal-associated membrane protein 2, LGP110, LAMPB, LAMP-2, CD107b |
| Ig Type | Rabbit IgG |
| 克隆号 | 1V86 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00683 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.37% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation. Plays a role in lysosomal protein degradation in response to starvation. Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes. Required for normal degradation of the contents of autophagosomes. Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens. Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human LAMP2 |
| 抗原种属 | Human |
| 基因ID | 3920 |
| Uniprot ID | |
| 研究领域 | Cardiovascular, Tags & Cell Markers |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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