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Anti-LAIR1 Antibody (3K641)
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产品编号 TMAY-03527
别名 leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305
Anti-LAIR1 Antibody (3K641) 是一种 Rabbit 抗体，靶向 LAIR1。Anti-LAIR1 Antibody (3K641) 可用于 ELISA。
Anti-LAIR1 Antibody (3K641)
Anti-LAIR1 Antibody (3K641)
还可以产品编号 TMAY-03527 别名 leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305
Anti-LAIR1 Antibody (3K641) 是一种 Rabbit 抗体，靶向 LAIR1。Anti-LAIR1 Antibody (3K641) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,279 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-LAIR1 Antibody (3K641) is a Rabbit antibody targeting LAIR1. Anti-LAIR1 Antibody (3K641) can be used in ELISA. |
| 别名 | leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305 |
| Ig Type | Rabbit IgG |
| 克隆号 | 3K641 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LAIR-1 / CD305 (rM LAIR-1 / CD305; TMPY-02598; Q8BG84-1; Gln22-Ser133). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Mouse LAIR-1 / CD305 Protein (TMPY-02598) |
| 抗原种属 | Mouse |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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