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LAIR1 Protein, Human, Recombinant (His & Avi), Biotinylated

产品编号 TMPY-05604

别名: CD305, leukocyte-associated immunoglobulin-like receptor 1, LAIR-1

LAIR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 19 kDa and the accession number is AAF71275.2.

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LAIR1 Protein, Human, Recombinant (His & Avi), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 2,940		5日内发货
100 μg	￥ 6,800		5日内发货

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生物活性	Testing in progress
产品描述	LAIR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 19 kDa and the accession number is AAF71275.2.

种属	Human
表达系统	HEK293 Cells
标签	His, Avi
蛋白编号	AAF71275.2
别名	CD305, leukocyte-associated immunoglobulin-like receptor 1, LAIR-1
蛋白构建	The Human LAIR1 (AAF71275.2) (Met1-Tyr165) was expressed with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	19 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.

参考文献

1. Meyaard, L. et al.,1997, Immunity.7:283-290. 2. Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804. 3. Meyaard, L. et al., 2001, J. Exp. Med. 194 (1): 107-112. 4. Meyaard, L., 2003, J Biol Regul Homeost Agents. 17 (4): 330-333. 5. Lebbink, R. J. et al., 2008, J Immunol. 180 (3):1662-1669. 6. Lebbink,R.J. et al., 2009, Matrix Biol. 28 (4):202-210.

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Keywords

LAIR1 Protein, Human, Recombinant (His & Avi), Biotinylated CD-305 LAIR 1 CD 305 CD305 LAIR1 leukocyte-associated immunoglobulin-like receptor 1 LAIR-1 recombinant recombinant-proteins proteins protein

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