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Anti-LRPAP1 Antibody (8W851)
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产品编号 TMAY-01638
别名 RAP, low density lipoprotein receptor-related protein associated protein 1, HBP44, C77774, AU042172, AI790446, AA617339
Anti-LRPAP1 Antibody (8W851) 是一种 Mouse 抗体，靶向 LRPAP1。Anti-LRPAP1 Antibody (8W851) 可用于 IHC-P。
Anti-LRPAP1 Antibody (8W851)
331 Anti-LRPAP1 Antibody (8W851)
还可以产品编号 TMAY-01638 别名 RAP, low density lipoprotein receptor-related protein associated protein 1, HBP44, C77774, AU042172, AI790446, AA617339
Anti-LRPAP1 Antibody (8W851) 是一种 Mouse 抗体，靶向 LRPAP1。Anti-LRPAP1 Antibody (8W851) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-LRPAP1 Antibody (8W851) is a Mouse antibody targeting LRPAP1. Anti-LRPAP1 Antibody (8W851) can be used in IHC-P. |
| 别名 | RAP, low density lipoprotein receptor-related protein associated protein 1, HBP44, C77774, AU042172, AI790446, AA617339 |
| Ig Type | Mouse IgG1 |
| 克隆号 | 8W851 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human LRPAP1 in human kidney with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule. 2. Immunochemical staining of human LRPAP1 in human hepatoma with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human LRPAP1 in human brain with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. Alpha-2-macroglobulin receptor-associated protein, also known as low-density lipoprotein receptor-related protein-associated protein 1, RAP, and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the low-density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on the cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330) and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin. Intron 5 insertion/deletion polymorphism of RAP gene (LRPAP1) has been implicated in other diseases sharing etiology with gallstone disease (GSD). The LRPAP1 insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiasis. The genetic variations at the LRPAP1 locus may modulate Alzheimer's disease (AD) phenotype beyond risk for disease. Also, the variation in the LRPAP1 gene could contribute to the risk of developing an early episode of myocardial infarction (MI). |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human LRPAP1 protein (TMPY-01233) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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