Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ciamexon (Ciamexone) 是一种新型的免疫调节剂,在自身免疫性疾病的实验模型中具有良好的效果,几乎没有显示出细胞毒性。Ciamexon 可用于研究内分泌眼病和糖尿病,在短时间给药后眼科疾病得到轻微改善。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 910 | 现货 | ||
5 mg | ¥ 2,230 | 现货 | ||
10 mg | ¥ 3,350 | 现货 | ||
25 mg | ¥ 5,460 | 现货 | ||
50 mg | ¥ 7,670 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,800 | 现货 |
产品描述 | Ciamexon (Ciamexone) is a novel immunomodulator that has shown promising results in experimental models of autoimmune disease with little demonstrated cytotoxicity.Ciamexon can be used to study endocrine ophthalmopathies and diabetes mellitus, with slight improvement in ophthalmic disease following short-term administration. |
体内活性 | Ciamexon on the development of diabetes in BB rats. Ciamexon was given once daily for 6 days per week beginning with the age of 42 or 50 days up to 120 days. For comparison, cyclosporin A (10 mg/kg) was applied following the same protocol. At 1 mg/kg, Ciamexon administration led to the complete prevention of diabetes in females but was not beneficial in males. At 10 mg/kg the drug caused significant suppression of diabetes development in males but more pronounced in females. Both, a reduction in the incidence of diabetes and a delay in the onset of hyperglycemia was observed only in females. After administration of cyclosporin A none of the animals developed diabetes. Ciamexon treatment did not affect granulocyte and lymphocyte counts and subsets in the peripheral blood except for a tendency to suppress eosinophilia. The growth of animals was not retarded. It is concluded that Ciamexon seems to influence the autoimmune state of the BB rat resulting in partial suppression of the disease.[1] |
别名 | Ciamexone, BM 41332, BM41332, BM-41332 |
分子量 | 203.24 |
分子式 | C11H13N3O |
CAS No. | 75985-31-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (270.62 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.9203 mL | 24.6015 mL | 49.2029 mL | 123.0073 mL |
5 mM | 0.9841 mL | 4.9203 mL | 9.8406 mL | 24.6015 mL | |
10 mM | 0.492 mL | 2.4601 mL | 4.9203 mL | 12.3007 mL | |
20 mM | 0.246 mL | 1.2301 mL | 2.4601 mL | 6.1504 mL | |
50 mM | 0.0984 mL | 0.492 mL | 0.9841 mL | 2.4601 mL | |
100 mM | 0.0492 mL | 0.246 mL | 0.492 mL | 1.2301 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ciamexon 75985-31-8 Others Ciamexone BM 41332 BM41332 BM-41332 Inhibitor inhibitor inhibit