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Anti-IRAK4 Antibody (3T950)
还可以产品编号 TMAH-00637
别名 REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4
Anti-IRAK4 Antibody (3T950) 是一种抗体，靶向 IRAK4。Anti-IRAK4 Antibody (3T950) 可用于 ELISA, WB, FC。
Anti-IRAK4 Antibody (3T950)
Anti-IRAK4 Antibody (3T950)
还可以产品编号 TMAH-00637 别名 REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4
Anti-IRAK4 Antibody (3T950) 是一种抗体，靶向 IRAK4。Anti-IRAK4 Antibody (3T950) 可用于 ELISA, WB, FC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-IRAK4 Antibody (3T950) is an antibody targeting IRAK4. Anti-IRAK4 Antibody (3T950) can be used in ELISA, WB, FC. |
| 别名 | REN64, NY-REN-64, IRAK-4, IPD1, interleukin-1 receptor-associated kinase 4 |
| Ig Type | Rabbit IgG |
| 克隆号 | 3T950 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: THP-1 whole cell lysate, U251 whole cell lysate -All lanes: IRAK4 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 52, 38 kDa -Observed band size: 55 kDa 2. Overlay histogram showing Jurkat cells stained with TMAH-00637 (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*10^6 cells) for 1 h at 4°C.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4°C. Control antibody (green line) was Rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| 应用 | ELISA, WB, FC |
| 推荐剂量 | WB:1:500-1:5000; FC:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human IRAK4 |
| 抗原种属 | Human |
| 基因ID | 51135 |
| Uniprot ID | |
| 研究领域 | Cardiovascular, Immunology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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