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Anti-USP7 Antibody (7H195)

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产品编号 TMAY-01988
别名 ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP

Anti-USP7 Antibody (7H195) 是一种 Mouse 抗体，靶向 USP7。Anti-USP7 Antibody (7H195) 可用于 ELISA,FCM。

Anti-USP7 Antibody (7H195)

Anti-USP7 Antibody (7H195)

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产品编号 TMAY-01988 别名 ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP

Anti-USP7 Antibody (7H195) 是一种 Mouse 抗体，靶向 USP7。Anti-USP7 Antibody (7H195) 可用于 ELISA,FCM。

规格价格库存数量
100 μL
¥ 1,679
5日内发货
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产品介绍

生物活性
产品描述
Anti-USP7 Antibody (7H195) is a Mouse antibody targeting USP7. Anti-USP7 Antibody (7H195) can be used in ELISA,FCM.
别名ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP
Ig Type
Mouse IgG2a
克隆号
7H195
交叉反应
Human
特异性
Human USP7
验证活性
Flow cytometric analysis of Human USP7 expression on Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human USP7, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用ELISAFCM
推荐剂量
ELISA: 1:1000-1:2000; FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human USP7 / HAUSP (rh USP7 / HAUSP; TMPY-01463; NP_003461.2; Lys208-Glu560). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein that belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP stimulates lytic infection and the reactivation of quiescent viral genomes. ICP interacts very strongly with USP7. USP7-mediated stabilization of ICP is dominant over ICP-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP are expressed.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human USP7 / HAUSP protein (TMPY-01463)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

ubiquitin specific peptidase 7TEF-1TEF 1herpes virus-associated

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