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TROP-2 Protein, Human, Recombinant (His)

产品编号 TMPY-01262

TROP-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.4 kDa and the accession number is P09758.

TROP-2 Protein, Human, Recombinant (His)

产品编号 TMPY-01262

TROP-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.4 kDa and the accession number is P09758.

规格	价格	库存	数量
100 μg	¥ 1,700	In stock

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产品信息

生物活性	1. Immobilized Anti-TROP2 Antibody at 2μg/mL (100 μL/well) can bind Recombinant Human TROP2/TACSTD2 Protein (His Tag) , the EC50 is 1.6-4.8 ng/mL._x000D_ 2. Loaded Anti-Human TROP2 antibody, human IgG1 on ProA Biosensor, can bind Recombinant Human TROP2 Protein, His Tag with an affinity constant of 1.64 nM as determined in BLI assay (Routinely tested).
产品描述	TROP-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.4 kDa and the accession number is P09758.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P09758
别名	tumor-associated calcium signal transducer 2,TROP-2,TROP2,TACD2,M1S1,GP50,GA733-1,GA7331,EGP-1,EGP1
蛋白构建	A DNA sequence encoding the extracellular domain (Met1-Thr274) of human TROP2 (NP_002344.2) was expressed fused with a polyhistidine tag at the C-terminus. Predicted N terminal: His 27
蛋白纯度	> 96 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC.
分子量	29.4 kDa (predicted); 42-48 kDa (reducing condition, due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.